Sapropterin reduces coronary artery malformation in offspring of pregestational diabetes mice

In conclusion, sapropterin treatment increases eNOS activity, reduces oxidative stress and prevents coronary artery malformation in offspring of pregestational diabetes. Sapropterin may have therapeutic potential in preventing coronary artery malformation in maternal diabetes.Graphical abstractOral sapropterin (Kuvan®) treatment inhibits oxidative stress, improves Akt/eNOS activity, and prevents coronary artery malformation (CAM) during pregestational diabetes.
Source: Nitric Oxide - Category: Chemistry Source Type: research