Early experience with preclinical peri-operative cardiac xenograft dysfunction in a single program.

CONCLUSIONS: Despite excellent surgical technique, uneventful weaning from CPB, and adequate initial function, orthotopic cardiac xenografts slowly fail within 24-48 hours without evidence of rejection. Modification of preservation techniques and minimizing donor organ ischemic time may be able to ameliorate PCXD. PMID: 31589847 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31589847?dopt=Abstract

Source: The Annals of Thoracic Surgery - October 3, 2019 Category: Cardiovascular & Thoracic Surgery Authors: DiChiacchio L, Singh AK, Lewis B, Zhang T, Hardy N, Pasrija C, Morales D, Odonkor P, Strauss E, Williams B, Deatrick KB, Kaczorowski DJ, Ayares D, Griffith BP, Bartlett ST, Mohiuddin MM Tags: Ann Thorac Surg Source Type: research