An App That Can Catch Early Signs Of Eye Disease In A Flash

After his son developed a rare eye cancer, a chemist in Texas developed a smart phone app that uses a camera and artificial intelligence to detect early signs of eye disease.(Image credit: Munson et al., Sci. Adv. 2019; 5 eaax 6363)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news

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ler Martina C. Herwig-Carl The BAP1 (BRCA1-associated protein 1) gene is associated with a variety of human cancers. With its gene product being a nuclear ubiquitin carboxy-terminal hydrolase with deubiquitinase activity, BAP1 acts as a tumor suppressor gene with potential pleiotropic effects in multiple tumor types. Herein, we focused specifically on uveal melanoma (UM) in which BAP1 mutations are associated with a metastasizing phenotype and decreased survival rates. We identified the ubiquitin carboxyl hydrolase (UCH) domain as a major hotspot region for the pathogenic mutations with a high evolutionary action (EA...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Source: Cancer Biotherapy and Radiopharmaceuticals - Category: Cancer & Oncology Authors: Source Type: research
In this study, we verified whether artificial intelligence could predict manual assessments of BAP1 expression in 47 enucleated eyes with uveal melanoma, collected from one European and one American referral center. Digitally scanned pathology slides were divided into 8176 patches, each with a size of 256 × 256 pixels. These were in turn divided into a training cohort of 6800 patches and a validation cohort of 1376 patches. A densely-connected classification network based on deep learning was then applied to each patch. This achieved a sensitivity of 97.1%, a specificity of 98.1%, an overall diagnostic accuracy o...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Fedele P, Sanna V, Fancellu A, Cinieri S Abstract Introduction: The dysregulation of cell cycle control can lead to cancer development. In breast cancer, cyclin D, CDK 4,6 and the retinoblastoma protein play a central role in the control of cell proliferation, in crosstalk with the estrogen receptor and Her2 pathways. Although the mechanisms by which the CDK4/6 complex is involved in the control of cell growth in triple negative breast cancer (TNBC) are still unclear, some TNBCs might be sensitive to CDK4/6 inhibitors. Areas covered: The authors provide an overview of the treatments that target cell cycle ...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
ConclusionOur data showed that non-canonical NF κB proteins were significantly higher in metastatic cases and associated with poor outcome of the patients. Furthermore, the p52 protein could be used as a potential therapeutic biomarker for metastatic cases in uveal melanoma.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Abstract Several lines of evidence have implicated LINE-1 (Long INterspersed nuclear Element-1) retroelement in the onset and progression of lung cancer. Retrotransposition-dependent mechanisms leading to DNA mobilization give rise to insertion mutations and DNA deletions, while retrotransposition-independent mechanisms disrupt epithelial programming and differentiation. Previous work by our group established that tobacco carcinogens like benzo(a)pyrene (BaP) reactivate LINE-1 in bronchial epithelial cells through displacement of NuRD corepressor complexes and interference with retinoblastoma-regulated epigenetic ...
Source: Am J Physiol Lung Ce... - Category: Respiratory Medicine Authors: Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
ConclusionsCollectively our data suggest that a nonselective beta ‐blocker may be effective against melanoma. For the first time, we show potent anti‐tumor effects in UM cells following propranolol administration and expression of β1 and β2 adrenoceptors in patient tissue.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Leukocoria, also known as white puppilary reflex, is a symptom of a number of diseases, including retinoblastoma, Coats’ disease, and congenital cataracts. When light enters the eye at certain angles in people with leukocoria, a white reflectio...
Source: Medgadget - Category: Medical Devices Authors: Tags: Ophthalmology Pediatrics Source Type: blogs
Kiilgaard Donia Svane Uveal melanoma (UM) is the most common intraocular malignancy in adults and shows a high rate of metastatic spread. As randomized clinical trials with immune checkpoint inhibitors (ICI) have not been performed in patients with metastatic UM, we analyzed the real-world outcomes in a nationwide population-based study. Clinical data of patients with UM were extracted from the Danish Metastatic Melanoma database, a nationwide database containing unselected records of patients diagnosed with metastatic melanoma in Denmark. Survival before (pre-ICI, n = 32) and after (post-ICI, n = 94) the appro...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Scientists from Baylor University in Waco, Texas, ran the app on more than 52,000 'casual photographs' of 20 children with a range of eye conditions and 20 healthy controls.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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