A mechanistic and empirical review of antcins, a new class of phytosterols of formosan fungi origin

Publication date: Available online 5 October 2019Source: Journal of Food and Drug AnalysisAuthor(s): K.J. Senthil Kumar, M. Gokila Vani, Chieh-Yin Chen, Wen-Wei Hsiao, Jing Li, Zhan-xi Lin, Fang-Hua Chu, Gow-Chin Yen, Sheng-Yang WangAbstractAntcins are unique phytosterols isolated from A. cinnamomea and A. salmomea, which are the endemic fungus of Taiwan. A. cinnamomea has long been highly valued medicinal mushroom in Taiwan and traditionally used as a folk remedy for various human illness. Recent scientific explorations claimed that the pharmacological activities of A. cinnamomea and A. salmomonea are gone beyond their original usage. The therapeutic efficacy of these medicinal mushrooms was attributed to their high content of unique bioactive secondary metabolites, including terpenoids, benzenoids, ubiquinol derivatives, polysaccharides, lignans, nucleic acids, steroids, and maleic/succinic acid derivatives. Antcins is a group of steroids in Antrodia spp. with ergostane skeleton received much attention in Taiwan's academic circle due to their broad-spectrum of biological activities. At present, twelve antcins, i.e. antcin A, B, C, D, E, F, G, H, I, K, M, and N along with twelve derivatives/epimers (25R/S-antcin A, B, C, H, I and K) and seven analogs (methyl antcinate A, B, G, H, K, L and N) were identified. Several studies have demonstrated that antcins possessed anti-cancer, anti-inflammation, anti-oxidant, anti-diabetic, anti-aging, immunomodulation, hepatoprotection, and...
Source: Journal of Food and Drug Analysis - Category: Food Science Source Type: research