Anti-pig antibody in infants: can a genetically-engineered pig heart bridge to allotransplantation?

ANTI-PIG ANTIBODY IN INFANTS: CAN A GENETICALLY-ENGINEERED PIG HEART BRIDGE TO ALLOTRANSPLANTATION? Ann Thorac Surg. 2019 Sep 30;: Authors: Li Q, Hara H, Banks CA, Yamamoto T, Ayares D, Mauchley DC, Dabal RJ, Padilla L, Carlo WF, Rhodes LA, Cooper DKC, Cleveland DC Abstract BACKGROUND: Congenital heart patients have high heart-transplant waitlist mortality, and mechanical support is suboptimal. To evaluate feasibility of cardiac grafts from a genetically-engineered triple-knockout pig as a bridge to allotransplantation, preformed anti-pig antibodies were measured in pediatric and adult patients. METHODS: Flow cytometry measured serum IgM/IgG binding to wild-type and triple-knockout red blood cells (RBCs), with binding to human O-negative RBCs as a negative control. Group 1: 84 pediatric patients and 64 healthy adults' sera with no previous cardiac surgery. Group 2: 25 infant's sera post-cardiac surgery, including 10 after palliation for hypoplastic left heart syndrome. RESULTS: Group 1: IgM binding to wild-type RBCs occurred in 80% and IgG binding in 91% sera. Only 3% sera showed IgM binding to triple-knockout RBCs, and one (
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research

Related Links:

ConclusionsWe found a significantly increased five-year survival rate for heart-kidney transplant recipients compared to isolated heart transplant recipients with renal impairment. Lack of improvement in five-year post-operative outcomes for heart-kidney recipients in the setting of higher risk pre-transplant clinical characteristics suggests decreased selectivity regarding heart-kidney recipients. Continued scrutiny and evaluation of post-operative outcomes are required to ensure just and appropriate utilization of organs.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Chiba Y, Fukushima A, Nakao M, Kobayashi Y, Ishigaki T, Tenma T, Kamiya K, Shingu Y, Ooka T, Matsui Y, Anzai T Abstract A 23-year-old man had progressive muscle weakness and Emery-Dreifuss muscular dystrophy (EDMD) due to a LMNA (lamin A/C) mutation. Congestive heart failure diagnosed at 19 years of age. Maximal drug treatment/cardiac resynchronization failed to improve the cardiac function. He was therefore hospitalized due to heart failure. Despite extracorporeal membrane oxygenation, he developed severe right heart dysfunction and died (multiple organ failure). A cardiac lesion's presence determines the...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conditions:   Heart Transplant Infection;   CMV Infection Intervention:   Diagnostic Test: ELISPOT IFN-γ assay Sponsors:   Hospital Universitari de Bellvitge;   Instituto de Salud Carlos III;   Sociedad Española de Cardiología Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Liver biopsy is the gold standard for diagnosing liver disease in patients undergoing evaluation for heart transplant. Obtaining an accurate assessment of the liver is crucial, as it predicts outcomes of heart transplantation. Transabdominal liver biopsy increases the risk of bleeding and can be dangerous due to the limited cardiac reserve of these patients, therefore transvenous approaches are preferable. Studies show that patients with congestive hepatopathy have heterogeneous involvement of the liver.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 22 Source Type: research
Publication date: Available online 18 February 2020Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Andrea De Gasperi, Gregorio Spagnolin, Martina Ornaghi, Laura Petrò, Gianni BiancofioreAbstractNew and extended indications, older age, higher cardiovascular risk, and the long-standing cirrhosis - associated complications mandate specific skills for an appropriate preoperative assessment of the LT candidate. The incidence of cardiac diseases (dysrhythmias, cardiomyopathies, coronary artery disease, valvular heart disease) are increasing among LT recipients: however, no consensus exists among cli...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
Conditions:   Hematopoietic Stem Cell Transplantation;   Bone Marrow Transplant;   Heart Rate Variability;   Autonomic Nervous System;   Stress;   Mood;   Psychological Distress;   Emotion Regulation;   Communication Research;   Narrative Interventions:   Behavioral: Baseline Surveys;   Behavioral: Heart rate variability biofeedback;   Behavioral: Heart rate variability waitlist and Digital storytelling Control intervention Sponsors:   Arizona State Univer...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Boucly A, Savale L, Vuillard C, Turpin M, Jaïs X, Montani D, Humbert M, Sitbon O Abstract Right ventricular failure (RVF) is a common cause of admission to the intensive care unit and its presence is a major prognostic factor in acute pulmonary embolism (PE) and chronic pulmonary hypertension (PH). RVF results from an incapacity of the RV to adapt to an increase in afterload so it can become critical in acute PE and chronic PH. The presence of RVF in cases of acute PE with haemodynamic instability is an indication for thrombolytic therapy. RVF represents the most common cause of death in chronic PH. F...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
This study enrolled an institutional consecutive surgical series of 24 patients with refractory congestive heart failure under peripheral ECLS, related to fulminant myocarditis (n = 15), dilated cardiomyopathy (n = 5), or acute myocardial infarction (n = 4). They were converted to central Y-extracorporeal membrane oxygenation (ECMO,n = 6), extracorporeal ventricular assist device (EC-VAD,n = 12), or pump catheter (n = 6), dependent upon the degree of multiorgan failure. Despite the different degree of multiorgan failure prior to the convers...
Source: Journal of Artificial Organs - Category: Transplant Surgery Source Type: research
AbstractCardiovascular diseases (CVDs) pose a serious threat to human health, which are characterized by high disability and mortality rate globally such as myocardial infarction (MI), atherosclerosis, and heart failure. Although stem cells transplantation and growth factors therapy are promising, their low survival rate and loss at the site of injury are major obstacles to this therapy. Recently, the development of hydrogel scaffold materials provides a new way to solve this problem, which have shown the potential to treat CVD. Among these scaffold materials, environmentally responsive hydrogels have great prospects in re...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Condition:   Acute Rejection of Cardiac Transplant Intervention:   Diagnostic Test: INNOGRAFT Heart Suite Sponsors:   Myway Gentics Srl;   Policlinico San Matteo Pavia Fondazione IRCCS;   Istituto Di Ricerche Farmacologiche Mario Negri Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Cardiology | Cardiovascular & Thoracic Surgery | Genetics | Heart | Heart Transplant | Pediatrics | Transplant Surgery | Transplants