Relationship between expression levels of circulating hsa-miR-125a-3p and hsa-miR-125b with breast cancer.

Relationship between expression levels of circulating hsa-miR-125a-3p and hsa-miR-125b with breast cancer. Br J Biomed Sci. 2019 Oct 02; Authors: Ramezani S, Talesh Sasani S, Fakor F, Alizadehsefat S Abstract Breast cancer is a major leading cause of cancer death in women in almost all countries,including developing countries. Circulating microRNAs have been detected as potential blood-based biomarkers for the prognosis and diagnosis of various diseases and malignancies, including breast cancer. we analyzed miR-125a-3p and miR-125b expression patterns in breast cancer women in comparison to healthy controls in Guilan province, Iran. Peripheral blood sampling was done from 90 breast cancer patients and the exprssion levels of the miRNAs assessed using qReal-Time PCR..The studied miRNAs have opposite expression levels. So that the mean expression level of miR-125a-3p in breast cancer patients significantly decreased by almost half as compared to healthy controls, while miR- 125b notably elevated by nearly twofold. PMID: 31575334 [PubMed - as supplied by publisher]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research