Transcranial sonography in atypical parkinsonism: How reliable is it in real clinical practice? A multicentre comprehensive study

Substantia nigra hyperechogenicity (SN+) in transcranial sonography (TCS) is frequent in Parkinson's disease (PD), while lenticular nucleus hyperechogenicity (LN+) and 3rd ventricle enlargement (3V+) are typical of Atypical Parkinsonisms (AP). However, there are no studies assessing the diagnostic yield of all TCS biomarkers in the three AP (progressive supranuclear palsy, PSP, multiple system atrophy, MSA, corticobasal degeneration, CBD). Previous references lack homogeneous criteria and data are incomprehensive.

Source: Parkinsonism and Related Disorders - September 30, 2019 Category: Neurology Authors: Araceli Alonso-Canovas, Jos é Ignacio Tembl Ferrairó, Irene Martínez-Torres, Jose Luis Lopez-Sendon Moreno, Isabel Parees-Moreno, Enric Monreal Laguillo, Paula Pérez Torre, Rafael Toledano Delgado, Guillermo García Ribas, Isabel Sastre Bataller, Jaim Source Type: research