Oleanane-type triterpenoid saponins from the roots of Polygala aureocauda Dunn.

Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Tran Hong Quang, Duong Thi Hai Yen, Nguyen Xuan Nhiem, Bui Huu Tai, Nguyen Thi Thanh Ngan, Hoang Le Tuan Anh, Hyuncheol Oh, Phan Van Kiem, Chau Van MinhAbstractPolygala aureocauda Dunn. (Polygalaceae) has been widely used in Vietnamese traditional medicine for the treatment of hepatitis, nephritis, sonasthenia, anaemia, back pain, and knee fatigue. Chemical investigation of a methanol extract of P. aureocauda roots resulted in the isolation of four new oleanane triterpenoid saponins (polyaureosides A–D) and two known ones (polygalasaponin XLVIII and arilloside A). Their structures were elucidated by comprehensive spectroscopic methods, including 1D and 2D NMR and mass spectra. Among the isolates, arilloside A showed a modest anti-inflammatory effect through inhibiting NO overproduction in LPS-stimulated RAW264.7 macrophages, with an IC50 value of 47.4 μM.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research