21PUveal melanoma cell lines depend on multiple signaling pathways for survival

ConclusionsThe sensitivity of GNAQ/11 mutation UM cell lines to 6 targeted drugs is heterogeneous and no single dominant signalling pathway was identified. This suggest that multiple, independent signal pathways contribute to the survival of UM. Thus, inhibition of any single pathway is unlikely to be effective in the treatment of majority of metastatic UM. Table:21P Summary of UM cell lines to each inhibitor. Combined result of cell viability assay and cell cycle analysisCell LineMutationTrametinibBEZ235NAV2729AEB071VerteporfinLXS196Mel270GNAQsensitivesensitivesensitivesensitivesensitivesensitiveOMM1GNA11resistantsensitiveintermediate sensitivitysensitivesensitivesensitive92.1GNAQresistantintermediate sensitivitysensitiveintermediate sensitivitysensitiveintermediate sensitivityMel202GNAQresistantintermediate sensitivitysensitiveintermediate sensitivitysensitiveintermediate sensitivityOMM1.3GNAQresistantintermediate sensitivityresistantintermediate sensitivityresistantintermediate sensitivityOMM1.5GNAQresistantresistantresistantintermediate sensitivityresistantintermediate sensitivityMP41GNA11resistantresistantresistantintermediate sensitivityresistantintermediate sensitivityMP46GNAQresistantresistantresistantresistantresistantintermediate sensitivityMP38GNAQresistantresistantresistantresistantresistantresistantMel290Nilresistantintermediate sensitivityresistantresistantresistantresistantMel285NilresistantresistantresistantresistantresistantresistantLegal entity responsible f...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research