Vaccination adherence to influenza, pneumococcal and hepatitis B virus in adult type 1 diabetes mellitus patients

Different abnormalities account for the increased risk of viral and bacterial infection in patients with diabetes mellitus (DM). Main irregularities include: decreased CD4/CD8 lymphocyte ratios, reduced monocyte phagocytic function and defects in interleukin-2 production [1 –6]. Individuals with DM are 6 time more likely to be hospitalized and 3 times more likely to die from complications of influenza or pneumonia when compared to those in general population [7]. People with DM have higher rates of hepatitis B due to contact with infected blood or through improper eq uipment use (glucose monitoring devices or infected needles) [8].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research

Related Links:

Already marketed as a medical food, the formulation which replaces gut bacteria that are deficient in type 2 diabetes appears to lower postprandial blood glucose levels and A1c.Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
In this study, we showed that hyper-O-GlcNAcylation reduced the expression of myogenin, a transcription factor critical for terminal muscle development, in C2C12 myoblasts differentiation by O-GlcNAcylation on Thr9 of myocyte-specific enhancer factor 2c. Furthermore, we showed that O-GlcNAcylation on Mef2c inhibited its DNA binding affinity to myogenin promoter. Taken together, we demonstrated that hyper-O-GlcNAcylation attenuates skeletal muscle differentiation by increased O-GlcNAcylation on Mef2c, which downregulates its DNA binding affinity. PMID: 32736694 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
In this study, we evaluated the effect of leonurine on dexamethasone -treated β-cells. Our data showed that leonurine inhibited dexamethasone-induced INS-1 cell apoptosis and facilitated cell proliferation. Moreover, leonurine attenuated dexamethasone-impaired insulin secretion in mice islets. Leonurine ameliorated dexamethasone-induced dephosphorylation of Akt, Bad and GSK-3β. Importantly, the protective role of leonurine on dexamethasone-induced cytotoxicity was blocked by LY294002 in INS-1 cells. Our findings revealed for the first time that leonurine could protect against dexamethasone-induced cytot...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
In this study, we observed that (EX-4)2-Fc also has anti-inflammatory functions in adipose tissue. After the treatment of diet-induced obesity (DIO) mice with (EX-4)2-Fc, we found that the inflammatory response in adipose tissue was significantly attenuated. (Ex-4)2-Fc can reduce obesity-associated proinflammatory cytokine levels and macrophage numbers in DIO mice. In addition, (EX-4)2-Fc treatment resulted in proinflammatory M1-type macrophages beginning to transform into anti-inflammatory M2-type macrophages. The inflammatory mitogen-activated protein kinase (MAPK) signalling pathway and nuclear factor kappa B (NF-&kappa...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
Abstract Zika virus (ZIKV) is a mosquito-borne flavivirus associated with Congenital Zika Syndrome (CZS), reflecting a wide range of congenital abnormalities in fetuses and infants infected with ZIKV before birth. ZIKV infections have also been associated with the neurological autoimmune disorder known as Guillian-Barré syndrome (GBS). To date, no vaccines or antiviral strategies are licensed for ZIKV. We used rational design to develop a novel ZIKV vaccine candidate using a Woodchuck Hepatitis core Antigen (WHcAg) Virus-Like Particle (VLP) scaffold for displaying selected antigens from the ZIKV Envelope (E...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
Publication date: Available online 1 August 2020Source: Antiviral ResearchAuthor(s): Dagmara Bialy, Holly Shelton
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 1 August 2020Source: Antiviral ResearchAuthor(s): Peter G. Mohr, Janelle Williams, Masato Tashiro, Victor A. Streltsov, Jennifer L. McKimm-Breschkin
Source: Antiviral Therapy - Category: Virology Source Type: research
ConclusionsThe overlap of people with IFG, IGT and elevated HbA1c is small, and some factors are associated with only one criterion. Knowledge on sociodemographic and socioeconomic risk factors can be used to effectively target interventions to people at high risk for type 2 diabetes.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
In this study, we investigated the seroprevalence of anti-hepatitis D virus (HDV) antibodies in hepatitis B surface antigen (HBsAg)-positive children after 25  years of obligatory vaccination of infants against hepatitis B virus. This cross-sectional study included 120 treatment-naïve HBsAg-positive children, with a male-to-female ratio of 1.8:1 and a mean age of 7.8 ± 3.8 years (range, 1-17 years). Mothers were positive for HBsAg in 96.6% of the cases. HBeAg-positive chronic infection was observed in 60% of the cases, HBeAg-positive chronic hepatitis in 12.5%, and HBeAg-negative ...
Source: Archives of Virology - Category: Virology Source Type: research
More News: Diabetes | Diabetes Mellitus | Diabetes Type 1 | Endocrinology | Hepatitis | Hepatitis B | Hepatitis Vaccine | Influenza | Influenza Vaccine | Meningitis Vaccine | Pneomococcal Vaccine | Pneumonia | Primary Care | Vaccines