Clinical and lifestyle factors found to reduce efficacy of hormone therapy

Clinical and lifestyle factors including BMI, surgical menopause, smoking, alcohol use and antifungal medication influence estradiol levels in menopausal women taking hormone therapy, according to a study presented at the North American Menopause Society annual meeting.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Abstract OBJECTIVE: To identify factors associated with serum estradiol (E2) levels among healthy postmenopausal women using hormone therapy (HT). METHODS: This is an unplanned post hoc analysis of data from ELITE (Early versus Late Intervention Trial with Estradiol), a randomized controlled trial of 1 mg oral E2 with or without vaginal progesterone in healthy early compared with late (
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
ConclusionsOur study supports a healthy lifestyle improving breast cancer prevention, postponing onset of disease, and extending life expectancy among breast cancer patients.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
This study investigated how a history of menopausal hormone therapy (MHT) impacts clinical outcomes overall and in different subgroups of breast cancer patients. The study included 814 primary breast cancer patients aged ≥50 years in Sweden (2002–2012) with follow-up until 2016. Associations between patient- and tumor characteristics, recurrences, and overall survival were analyzed in relation to MHT. After a median follow-up of 7 years, 119 recurrences, and 111 deaths occurred. Ever MHT (n = 433, 53.2%) was associated with a lower BMI, frequency of alcohol abstinence, and histological grade, higher frequency of o...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Sleep disturbances such as insomnia are extremely common, especially in women after menopause. According to data from the National Institutes of Health, sleep disturbance varies from 16% to 42% before menopause, from 39% to 47% during perimenopause, and from 35% to 60% after menopause. Insomnia is a serious medical problem defined by frequent difficulty falling or staying asleep that impacts a person’s life in a negative way. Hormone changes around menopause can lead to sleep problems for many reasons, including changing sleep requirements, increased irritability, and hot flashes. What menopausal women eat could have...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Fatigue Food as medicine Healthy Eating Menopause Nutrition Sleep Source Type: blogs
Conclusions: A higher education level may be associated with an increased risk of developing breast cancer, in which alcohol use, age at menopause, and hormone therapy may, at least partially, play a mediating role.
Source: Menopause - Category: OBGYN Tags: Review Article Source Type: research
Lifestyle factors such as alcohol use and smoking alter estradiol levels in women receiving hormone therapy, according to a study presented at the North American Menopause Society Annual Meeting.Medscape
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
AbstractIncidence of non-alcoholic fatty liver disease (NAFLD) and liver cancer are 2 –3 times higher in males than females. Hormonal mechanisms are hypothesized, with studies suggesting that oophorectomy may increase risk, but population-based evidence is limited. Thus, we conducted a study within the Clinical Practice Research Datalink, with controls matched to cases of NAFLD (n  = 10,082 cases/40,344 controls) and liver cancer (n = 767 cases/3068 controls). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Effect measure modificatio...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
MHT containing natural estrogen and natural progesterone and some progestogens, is an effective treatment and is safer to the breast than high dose (0,625 mg or more) of equine estrogen with MPA. This latter treatment is associated with a higher incidence of breast cancer, in the range of the higher incidence of breast cancer due to drinking two or more alcohol drinks per day or gaining five of or more kilograms of weight. In women, at risk for breast cancer, with menopausal complaints special attention much be made to prescribe breast safe hormonal therapy.
Source: Maturitas - Category: Primary Care Authors: Tags: INV42 Source Type: research
Conclusions: Serum E2 levels may help to identify women at higher risk of fractures over the menopausal transition. However, hormone assays must be standardized across laboratories for clinical implementation and further work is needed to define E2 thresholds. PMID: 30690517 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
CONCLUSIONS: Contemporary MHT does not seem to increase the risk of biliary tract cancer. The decreased risk of gallbladder cancer may be explained by the increased use of surgery for symptomatic gallstones in MHT users. PMID: 30656997 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
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