Pharmacokinetics and pharmacodynamic effects of oral transmucosal and intravenous administration of dexmedetomidine in dogs.

CONCLUSIONS AND CLINICAL RELEVANCE: OTM administration of the injectable formulation of dexmedetomidine resulted in a similar degree of sedation and prolonged duration of action, compared with results for IV administration, despite relatively low bioavailability.
PMID: 31556717 [PubMed - in process]

Source: American Journal of Veterinary Research - September 28, 2019 Category: Veterinary Research Authors: Dent BT, Aarnes TK, Wavreille VA, Lakritz J, Lerche P, KuKanich B, Riccó Pereira CH, Bednarski RM Tags: Am J Vet Res Source Type: research