Age and Sex Distribution of Chinese Chronic Cough Patients and Their Relationship With Capsaicin Cough Sensitivity.

This study aimed to explore the age and sex distribution as well as their relationship with cough reflex sensitivity to capsaicin in Chinese chronic cough patients. METHODS: We analyzed the demographic features of 1,882 consecutive chronic cough patients who attended our cough clinic in Guangzhou, China. Cough sensitivity to capsaicin, which was defined as the lowest concentration of capsaicin causing 5 coughs or more (C5), was measured in 539 of the 1,882 patients and 68 healthy volunteers. RESULTS: The mean age of the patients was 43.0 ± 13.7 years and patients aged
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

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Cough is a common and troublesome symptom in patients with asthma, in whom the interactions among airway hyperactivity, bronchospasm, airway wall inflammation, and inevitable environmental exposures (allergens, viruses, and irritants) make effective management of cough a clinical challenge. How then do we understand the etiology of cough, and how can we use that understanding to improve care of patients with asthma? The study by Satia et  al1 in this issue of the Journal suggests that airway inflammation from allergen exposure and consequent bronchospasm are associated with increased sensitivity of the capsaicin-induced cough reflex.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research
Authors: Song DJ, Song WJ, Kwon JW, Kim GW, Kim MA, Kim MY, Kim MH, Kim SH, Kim SH, Kim SH, Kim ST, Kim SH, Kim JK, Kim JH, Kim HJ, Kim HB, Park KH, Yoon JK, Lee BJ, Lee SE, Lee YM, Lee YJ, Lim KH, Jeon YH, Jo EJ, Jee YK, Jin HJ, Choi SH, Hur GY, Cho SH, Kim SH, Lim DH Abstract Chronic cough is common in the community and causes significant morbidity. Several factors may underlie this problem, but comorbid conditions located at sensory nerve endings that regulate the cough reflex, including rhinitis, rhinosinusitis, asthma, eosinophilic bronchitis, and gastroesophageal reflux disease, are considered important. Howe...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
ConclusionTiotropium may alleviate asthmatic cough refractory to ICS/LABA by modulating cough reflex sensitivity but not through bronchodilation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Conclusion Tiotropium may alleviate asthmatic cough refractory to ICS/LABA by modulating cough reflex sensitivity but not through bronchodilation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Conclusion Tiotropium may alleviate asthmatic cough refractory to ICS/LABA by modulating cough reflex sensitivity but not thorough bronchodilation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
BY ​SEMERE TEDLA, MD; WESLEY EILBERT, MD; &JOSEPH COLLA, MD​A 59-year-old man with a history of frequent crack cocaine use presented with difficulty breathing for four hours. He had no prior medical problems or known allergies. He admitted to smoking crack cocaine four days before his symptoms began. He reported a one-day history of productive cough but denied chest pain, sore throat, and fever.​​He was a well-developed man in mild distress. His temperature was 36.5°C, pulse 90 bpm, blood pressure 188/108 mm Hg, and respiratory rate 20 bpm. His oxygen saturation was 100% on four liters by nasal cannula. Ins...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
Authors: Song WJ, Morice AH Abstract Cough reflex is a vital protective mechanism against aspiration, but when dysregulated, it can become hypersensitive. In fact, chronic cough is a significant medical problem with a high degree of morbidity. Recently, a unifying paradigm of cough hypersensitivity syndrome has been proposed. It represents a clinical entity in which chronic cough is a major presenting problem, regardless of the underlying condition. Although it remains a theoretical construct, emerging evidence suggests that aberrant neurophysiology is the common etiology of this syndrome. Recent success in randomi...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Background: Cough is the archetypal airway reflex but it is unclear if there is an interaction between bronchoconstriction and cough reflex responses in asthma.Objective: To investigate the interaction between bronchoconstriction and cough in subjects with mild atopic asthma.Methods: For each subjects we determined the methacholine PC20 and the dose of capsaicin required to cause half the maximal response (ED50). Subjects underwent three interventions in a randomised single-blinded placebo controlled manner to assess the effects of:1;bronchoconstriction on evoked coughs,2;evoked coughs on bronchoconstriction,3;spontaneous ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 5.3 Allergy and Immunology Source Type: research
CONCLUSION: The endoscopist expressed her approval of spraying lidocaine for taking less time to start the procedure, ease for instrumentation, less gag reflex during the procedure, less presence of hypersecretion, and smooth operation. However participants favored nebulized lidocaine administration. PMID: 27501598 [PubMed - in process]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - Category: Journals (General) Tags: J Med Assoc Thai Source Type: research
Discussion Regurgitation is a passive expulsion of ingested material out of the mouth. It is a normal part of digestion for ruminants such as cows and camels. Nausea is an unpleasant abdominal perception that the person may describe as feeling ill to the stomach, or feeling like he/she is going to vomit. Anorexia is frequently observed. Nausea is usually associated with decreased stomach activity and motility in the small intestine. Parasympathetic activity may be increased causing pale skin, sweating, hypersalivation and possible vasovagal syndrome (hypotension and bradycardia). Retching or dry heaves is when there are sp...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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