Disease- Modifying Effect of Anthraquinone Prodrug with Boswellic Acid on Collagenase-induced Osteoarthritis in Wistar Rats.

In conclusion, the conjugate at the specified dose level of 15.73 mg/kg, p. o. (BID) showed reduction in knee diameter and it could significantly normalize the hematological and biochemical abnormalities in collagenase-induced osteoarthritis in rats. Further the histopathological studies confirmed the additive anti-arthritic effect of DSRB as compared to plain rhein. PMID: 23701173 [PubMed - as supplied by publisher]
Source: Inflammation and Allergy Drug Targets - Category: Allergy & Immunology Authors: Tags: Inflamm Allergy Drug Targets Source Type: research