Computational models of the atrial fibrillation substrate: can they explain post-ablation recurrences and help to prevent them

This editorial refers to ‘Arrhythmogenic propensity of the fibrotic substrate after AF ablation: a longitudinal study using MRI-based atrial models’ by R.L. Aliet al., pp.1757 –1765.
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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There are new developments surrounding Verily Life Science’s prescription-only smartwatch. FDA has granted a new clearance for the South San Francisco-based company’s Study Watch to measure irregular heartbeats. The clearance comes one year after Verily received its first 510(k) clearance for ECG for the wrist-worn, sensor-based device. Verily announced in September of 2019 that it collaborated with iRhythm to develop solutions aimed at the Study Watch to improve the screening, diagnosis, and management of patients with atrial fibrillation (AFib). The collaboration brings together iRhyth...
Source: MDDI - Category: Medical Devices Authors: Tags: Regulatory and Compliance Digital Health Source Type: news
Studies have shown an increased prevalence of AF among athletes. Are usual AF treatments equally efficacious in athletes and non-athletes? How does continued exercise training influence outcome?Europace
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
ABSTRACTBackgroundAtrial fibrillation (AF) is associated with heart failure (HF) rehospitalization in patients with heart failure with preserved ejection fraction (HFpEF).ObjectiveWe tested the hypothesis that catheter ablation of AF could reduce HF rehospitalization compared with conventional pharmacotherapy in patients with HFpEF.MethodsEighty ‐five consecutive HFpEF (EF≥50% and a history of HF hospitalization) patients diagnosed as AF by 12‐lead electrocardiogram were retrospectively analyzed. Thirty‐five patients who received catheter ablation (ABL group) were compared with 50 patients treated by anti‐arrhyt...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionsIn this relatively young, oligosymptomatic, and with regard to the protocol without major comorbidities patient cohort, the overall costs are lower than expected compared with the HFrEF population. Further investigation is needed to investigate the impact of, for example, comorbidities and their effect over a longer period of time. Simultaneously, this analysis suggests that prevention of comorbidities are necessary to reduce costs in the health care system.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
AbstractAlthough treatment of atrial fibrillation (AF) classically focuses on eliminating the pulmonary vein (PV) triggers, isolation of PVs is associated with limited success rates in patients with persistent AF. The role of the left atrial appendage (LAA) as both trigger and driver in arrhythmogenesis of AF was previously demonstrated. In the present case, fractionation mapping software of Ensite system was firstly tested to detect critical substrate during AF. Focusing on the width and continuity of fractionation pattern, the LAA was accepted as main driver for maintenance of AF. Ablation in fractionated electrograms ar...
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
Pulmonary vein isolation (PVI) is the cornerstone of atrial fibrillation (AF) ablation. Radiofrequency (RF) represents a standard of care for PVI, while, cryoballoon (CB) ablation has emerged as a valid alternative. The aim of our meta-analysis was to explore the efficacy and safety of CB compared with RF as first ablation procedure for AF. We searched the literature for studies that investigated this issue. The primary efficacy outcome was AF recurrence. The safety outcomes were: pericardial effusion, cardiac tamponade, phrenic nerve palsy, vascular complications, and major bleedings.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Atrial Fibrillation is the leading cause of embolic stroke, yet less than half of high-risk patients with atrial fibrillation are on adequate stroke prevention with oral anticoagulants. Guidelines for the primary prevention of stroke recognize the emergency department as a location for physicians to identify atrial fibrillation and initiate anticoagulants. We sought to compare anticoagulant prescription rates in patients with atrial fibrillation in various provider settings to identify opportunities for improvement in cardioembolic stroke prevention.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
Publication date: Available online 25 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Juliane Herm, Alexander Schirdewan, Lydia Koch, Alexander Wutzler, Jochen B. Fiebach, Matthias Endres, Ute A. Kopp, Karl Georg HaeuslerAbstractAtrial fibrillation (AF) is associated with cognitive decline and dementia irrespective of AF-related ischemic stroke. We investigated whether AF burden after ablation in patients with symptomatic paroxysmal AF has an impact on cognitive function. After enrolment to the prospective MACPAF study, study patients received an insertable loop recorder (ILR) and underwent serial neurologic...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 25 January 2020Source: Life Sciences in Space ResearchAuthor(s): Deivydas Kiznys, Jone Vencloviene, Irena MilvidaitėAbstractIt is shown the statistical associations between space weather pattern and humans’ cardiovascular system. We investigated the association between space weather events and cardiovascular characteristics of 4076 randomly selected patients with acute coronary syndrome (ACS) who were admitted for inpatient treatment in Kaunas city, Lithuania during 2000–2005. We hypothesized that days of the space weather events, 1–3 days after, and the period between ...
Source: Life Sciences in Space Research - Category: Biology Source Type: research
AbstractAimsTo investigate the significance of early recurrence (ER) of atrial tachyarrhythmias after pulmonary vein isolation (PVI) on the development of late recurrence (LR) and to redefine the blanking period during which an ER is considered nonspecific.MethodsData of 713 patients undergoing their first PVI for paroxysmal or persistent atrial fibrillation between January 2012 and December 2017 were included. All patients were followed ‐up for 12 months according to clinical and outpatient routine and were screened for any atrial tachyarrhythmia lasting>30sec occurring during the first 3 months post ‐ablation (ER)...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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