Joint Associations of Maternal Gestational Diabetes and Hypertensive Disorders of Pregnancy With Overweight in Offspring

Objectives: Either maternal gestational diabetes mellitus (GDM) or hypertensive disorder of pregnancy (HDP) is associated with an increased risk of obesity in the offspring. However, their joint associations with obesity in offspring remain unclear. We investigated the joint associations of maternal GDM and HDP with childhood overweight in offspring.Methods: We performed a large study in 1967 mother-child pairs. Maternal GDM was diagnosed according to the 1999 World Health Organization (WHO) criteria. HDP was defined as self-reported doctor-diagnosed hypertension or treatment of hypertension (including gestational hypertension, preeclampsia, sever preeclampsia or eclampsia) after 20 weeks of gestation on the questionnaire. Body mass index (BMI) for age Z-score and childhood overweight were evaluated according to WHO growth reference. We used the general linear models to compare children's Z score for BMI and logistic regression models to estimate odds ratios of childhood overweight according to maternal different status of GDM and HDP.Results: Offspring of mothers with both GDM and HDP had a higher BMI for age Z-score (0.63 vs. 0.03, P
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

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Source: Risk Management and Healthcare Policy - Category: Health Management Tags: Risk Management and Healthcare Policy Source Type: research
CONCLUSIONS: Type 1 diabetes in both genders and all ages was associated with significantly elevated SMRs for all-cause and mostly for diabetes per se and renal disease. PMID: 32741854 [PubMed - as supplied by publisher]
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
Publication date: Available online 3 August 2020Source: Respiratory Medicine Case ReportsAuthor(s): Debasish Roychoudhury, Kenneth Sha, Navin C. Nanda, Gregory Gustafson
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Obesity is a risk factor for pregnancy-induced hypertension (PIH), Pre-Eclampsia (PE), Gestational Diabetes Mellitus (GDM) and Large Gestational Age (LGA) pregnancy. Bariatric surgery is widely accepted to treat obesity but associated with small for gestational age (SGA) fetuses.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
INTRODUCTION: Pregnancy is a risk factor for venous thromboembolism (VTE) and VTE affects 1 in 500 to 1 in 2000 pregnancies. Up to 30-50% of women with pregnancy-associated VTE may have an inherited thrombophilia but this does not completely explain the thrombosis risk. Clinical risk factors for VTE including multiple births, inflammatory bowel disease, sickle cell disease, diabetes, increased maternal age, stillbirth, and smoking have been identified in relatively small cohorts. We conducted this large case-control study to identify patient and pregnancy-associated risk factors for VTE during pregnancy or within 6 weeks p...
Source: Blood - Category: Hematology Authors: Tags: 331. Pathophysiology of Thrombosis: Poster III Source Type: research
CONCLUSIONS: There is insufficient evidence to support the use of metformin for women with obesity in pregnancy for improving maternal and infant outcomes. Metformin was, however, associated with increased risk of adverse effects, particularly diarrhoea. The quality of the evidence in this review varied from high to low, with downgrading decisions based on study limitations and inconsistency.There were only a small number of studies included in this review. Furthermore, none of the included studies included women categorised as 'overweight' and no trials looked at metformin in combination with another treatment.Future rese...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
BackgroundThe adoption of the International Association of Diabetes Study Groups (IADPSG) criteria for gestational diabetes mellitus (GDM) in Australia has been controversial. Obesity in pregnancy is also a growing concern. AimsTo assess the impact of IADPSG criteria on the incidence of GDM and pregnancy outcomes, and to compare this to the effect of obesity, particularly among women who would not have GDM by the Australasian Diabetes in Pregnancy Society 1998 criteria (ADIPS1998). Material and MethodsA retrospective observational cohort study linking results of 75 g glucose tolerance tests with demographic and pregna...
Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: Original Article Source Type: research
CONCLUSIONS: Very low-quality evidence from five trials suggests a possible reduction in GDM risk for women receiving dietary advice versus standard care, and low-quality evidence from four trials suggests no clear difference for women receiving low- versus moderate- to high-GI dietary advice. A possible reduction in pregnancy-induced hypertension for women receiving dietary advice was observed and no clear differences were seen for other reported primary outcomes. There were few outcome data for secondary outcomes.For outcomes assessed using GRADE, evidence was considered to be low to very low quality, with downgrading ba...
Source: Cochrane Database of Systematic Reviews - Category: Journals (General) Authors: Tags: Cochrane Database Syst Rev Source Type: research
Recent advances in molecular and imaging technologies, “omics” fields, and data sciences are offering researchers an unprecedented look at the placenta, the master regulator of the fetal environment.© EPA/National Geographic Channel/Alamy Studies of infants conceived during the Dutch “Hunger Winter” provided some of the earliest clues that prenatal stress could affect health much later in life.© Nationaal Archief  © Evan Oto/Science Source In one study, the placental microbiome had a similar taxonomic profile as the oral...
Source: EHP Research - Category: Environmental Health Authors: Tags: Featured Focus News July 2016 Source Type: research
Abstract AimTo examine the association between glucose level during pregnancy and the subsequent development of long‐term maternal atherosclerotic morbidity. MethodsA retrospective case–control study was conducted. The study included all women who had at least one glucose measurement during their pregnancies. Cases were all women who delivered between the years 2000–2012 and subsequently developed atherosclerotic morbidity (n = 815). Controls were randomly matched by age and year of delivery (n = 6065). The atherosclerotic morbidity group was further divided by severity: major events (card...
Source: Diabetic Medicine - Category: Endocrinology Authors: Tags: Research Article Source Type: research
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