A Nucleolar PARtnership Expands PARP Roles in RNA Biology and the Clinical Potential of PARP Inhibitors

In this issue of Molecular Cell, Kim et  al. (2019) identify small nucleolar RNAs (snoRNAs) as activators of poly(ADP-ribose) (PAR) synthesis, demonstrating that this snoRNA–PAR partnership promotes cancer cell growth independent of DNA repair pathways.
Source: Molecular Cell - Category: Cytology Authors: Tags: Preview Source Type: research