Podocyte lipotoxicity in diabetic kidney disease

Diabetic kidney disease (DKD) results from a complex interplay between genetics, environment, and behavioral factors. Hyperglycemia-induced metabolic alterations, including changes in energy utilization and mitochondrial dysfunction, play critical roles in disease initiation. Although DKD has long been regarded as a microvascular complication of diabetes, reduced podocyte number was also shown to correlate strongly with albuminuria and loss of glomerular filtration rate (GFR) in Pima Native Americans with type 2 diabetes.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Digest Source Type: research