Long-Term Gender-Based Outcomes for Atazanavir/Ritonavir (ATV/r) - Containing Regimens in Treatment-Experienced Patients with HIV.

Long-Term Gender-Based Outcomes for Atazanavir/Ritonavir (ATV/r) - Containing Regimens in Treatment-Experienced Patients with HIV. Curr HIV Res. 2013 Apr 12; Authors: Svedhem-Johansson V, Pugliese P, Brockmeyer NH, Thalme A, Michalik C, Esser S, Barlet MH, Nakonz T, Jimenez-Exposito MJ Abstract Clinical data on antiretroviral effectiveness in women is limited, especially long-term data, because women are usually underrepresented in clinical trials. This sub-analysis of a large European non-comparative, retrospective, observational cohort study evaluated gender differences in long-term outcomes in antiretroviral-experienced adult patients with HIV-1 infection switched to an ATV/r-based regimen between October 2004 and March 2007. Data were extracted from 3 European HIV databases every 6 months (maximum follow-up 5 years). Time to virological failure (VF), defined as two consecutive HIV-1 RNA ≥50 c/mL or one HIV-1 RNA ≥50 c/mL followed by treatment discontinuation (TD), and time to TD were analyzed using the Kaplan-Meier method. Associations of gender with VF and TD were analyzed using multivariate Cox proportional models. Safety and tolerability were evaluated. In total, 1294 patients (336 women, 958 men) were analyzed. No gender differences in time to VF were observed; at 3 years, the probability of not having VF was 0.59 (95%CI: 0.52, 0.65) and 0.63 (95%CI: 0.59, 0.67) for women and men, respectively. In multivariate analyses, women had a...
Source: Current HIV Research - Category: Infectious Diseases Authors: Tags: Curr HIV Res Source Type: research