Association Between Low-Dose Rivaroxaban With or Without Aspirin and Ischemic Stroke Subtypes

This secondary analysis of a multinational randomized clinical trial of 27  395 participants with systemic atherosclerotic disease examines the association low-dose rivaroxaban plus aspirin, rivaroxaban alone, or aspirin alone and the risk of different ischemic stroke subtypes.
Source: JAMA Neurology - Category: Neurology Source Type: research

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Publication date: Available online 28 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Luis Weitbrecht, Daniel Berchtold, Tian Zhang, Sandra Jagdmann, Claudia Dames, Katarzyna Winek, Christian Meisel, Andreas Meisel
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Authors: Smadja D, Salmon PK Abstract Health professionals are currently facing the challenge of managing an increasing number of old patients presenting with acute stroke, due to rapid aging of the population. Compared to their younger counterparts, elderly patients differ in many ways in the setting of acute stroke. Apart from a striking high stroke incidence, which increases exponentially as age increases, cardioembolism also becomes, as patients age, the main cause of ischemic stroke. Delirium, which can challenge the diagnosis, is frequent at the acute phase of stroke, and may be related to an underlying demen...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Publication date: Available online 28 September 2020Source: Pharmacology &TherapeuticsAuthor(s): Tao Tao, Maozhu Liu, Mengyuan Chen, Ying Luo, Cheng Wang, Tongtong Xu, Yixu Jiang, Yiyan Guo, John H. Zhang
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Background and Objectives: The benefit of tissue plasminogen activator (tPA) in acute ischemic stroke is time dependent. A 15-minute decrease in door-to-needle (DTN) time has been associated with increased odds of ambulating independently, faster discharge, and decreased odds of death. We investigated common causes of delay in DTN times in a community hospital setting in order to identify areas for improvement. Methods: A retrospective medical record review was conducted at a 574-bed community hospital. This included 100 patients who received tPA from 2016 to 2019. Time segments were classified a priori to reflect key...
Source: Quality Management in Healthcare - Category: Health Management Tags: Original Research Source Type: research
The immunolocalization of apoptotic factors in rat neocortex was studied on the model of permanent occlusion of the middle cerebral artery with administration of exogenous BDNF. We revealed heterogeneous distribution of pro- and anti-apoptotic factors in the stroke area and in the surrounding penumbra, where caspase-3+ and p53+ cells were found. Their number was maximum on day 3 of ischemia. The number of neurons containing anti-apoptotic factors was relatively decreased. Injection of BDNF changed the distribution of apoptotic factors. In the penumbra area, BDNF enhanced the expression of Mdm2 primarily in the pyramid cell...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
This review of current literature provides background to the COVID-19 pandemic, as well as an examination of potential pathophysiologic mechanisms behind development of thrombosis and ischemic stroke related to COVID-19. SARS-CoV-2 infection is well-documented to cause severe pneumonia, however, thrombosis and thrombotic complications, such as ischemic stroke, have also been documented in a variety of patient demographics. SARS-CoV-2 infection is known to cause a significant inflammatory response, as well as invasion of vascular endothelial cells, resulting in endothelial dysfunction.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
In Reply We thank Zhao et al for the interest in our randomized clinical trial. We agree that it is of interest to evaluate remote ischemic perconditioning specifically in patients with acute ischemic stroke and mismatch. We did not target these patients exclusively, because when the Remote Ischemic Conditioning in Acute Brain Infarction (RESCUE BRAIN) was designed in 2012, there was no proof of the efficacy of this approach; the DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo (DAWN) and Endovascular Therapy Following Imaging Evaluati...
Source: JAMA Neurology - Category: Neurology Source Type: research
To the Editor We read with interest the article by Pico et al, who reported the results of a randomized clinical trial to determine whether remote ischemic perconditioning can reduce brain infarction volume growth in patients with acute ischemic stroke. In the study, treatment with remote ischemic perconditioning had no significant effect on brain infarction volume growth at 24 hours after symptom onset. Two main hypotheses were proposed for the neutral results: remote ischemic perconditioning may not have any beneficial effect, or this trial mainly recruited patients who had received reperfusion therapies. However, we con...
Source: JAMA Neurology - Category: Neurology Source Type: research
We examined the association between LDL-C levels and incident stroke in patients with atrial fibrillation treated with direct oral anticoagulants (DOACs).
Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research
In this study, the clinical significance of serum RAGE levels in acute ischemic stroke patients with type 2 diabetes was determined.MethodThree hundred seven patients (165 patients without diabetes and 142 patients with diabetes) with acute cerebral infarction (ACI) were enrolled over 3 consecutive months. On admission, their National Institute of Health Stroke Scale (NIHSS) scores were recorded. The clinical laboratory data of all subjects were collected, and their serum levels of RAGE were assayed using enzyme-linked immunosorbent assay (ELISA). On admission and 3 months after stroke, the clinical outcomes were assessed ...
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
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