Estimating helminth burdens using sibship reconstruction

Sibship reconstruction is a form of parentage analysis that can be used to identify the number of helminth parental genotypes infecting individual hosts using genetic data on only their offspring. This has the...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research

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In this study, dependency of antibody production in Leishmania infection on BAFF was examined by using BAFF-knockout (BAFF-KO) mice. When BAFF-KO mice were infected with L. major, there was no significant difference in lesion development or parasite burden from those in infected wildtype mice. In contrast, levels of IgG antibodies to Leishmania crude antigen were lower in BAFF-KO mice, suggesting that antibody production during L. major infection is BAFF-dependent. ELISA using defined leishmanial antigens demonstrated that the influence of BAFF on antibody production during L. major varies depending on antigens; IgG produc...
Source: Parasitology International - Category: Parasitology Source Type: research
Publication date: Available online 15 October 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Sona Jain, Thyago Gois Costa Melo, Silvio Santana Dolabella, Juewen LiuAbstractWater-borne protozoan parasites like Cryptosporidium, Giardia, Entamoeba and Toxoplasma are responsible for 1.7 billion cases of diarrhea globally, representing the second most frequent reason for mortality among children under five. They show an environmentally resistant cyst/oocyst stage. Despite their importance, the standard analytical methods for their detection still rely on immunostaining followed by microscopic analysis. In recent year...
Source: TrAC Trends in Analytical Chemistry - Category: Chemistry Source Type: research
This study aimed to evaluate the efficacy of conventional smear cytology (SC), liquid-based cytology (LBC), cell block (CB) stained with haematoxylin and eosin (HE) and immunocytochemistry (ICC), and formalin-fixed paraffin wax-embedded tissue immunohistochemistry (FFPE–IHC) compared with serology and polymerase chain reaction for the diagnosis of canine visceral leishmaniosis (CVL) in lymphoid tissue. The use of a preservative medium and centrifugation for cytological samples reduced the number of unsatisfactory artefacts/background. Moreover, LBC allowed excellent cellular preservation and the application of ancill...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Malaria elimination requires diagnostic methods able to detect parasite levels well below what is currently possible with microscopy and rapid diagnostic tests. This is particularly true in surveillance of mal...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
chmidt In the course of our investigations on the antitrypanosomal potential of sesquiterpene lactones (STL), we have recently reported on the exceptionally strong activity of 4,15-iso-Atriplicolide tiglate, which demonstrated an IC50 value of 15 nM against Trypanosoma brucei rhodesiense, the etiologic agent responsible for East African human trypanosomiasis (HAT). Since STLs are known to often interact with their biological targets (e.g., in anti-inflammatory and anti-tumor activity) by means of the covalent modification of biological nucleophiles—most prominently free cysteine thiol groups in proteins&m...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
by Angela Nalwoga, Emily L. Webb, Belinda Chihota, Wendell Miley, Bridgious Walusimbi, Jacent Nassuuna, Richard E. Sanya, Gyaviira Nkurunungi, Nazzarena Labo, Alison M. Elliott, Stephen Cose, Denise Whitby, Robert Newton We investigated the impact of helminths and malaria infection on Kaposi’s sarcoma associated herpesvirus (KSHV) seropositivity, using samples and data collected from a cluster-randomised trial of intensive versus standard anthelminthic treatment. The trial was carried out in 2012 to 2016 among f ishing communities on Lake Victoria islands in Uganda. Plasma samples from 2881 participants from two hou...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
ConclusionOur findings indicate that cryptic myiasis cases due to the obligate parasite,C.bezziana, are under-recognized. Through this study onC.bezziana etiology, clinical features, diagnosis, treatment, epidemiology, prevention and control, we call for more vigilance and awareness of the disease from governments, health authorities, clinicians, veterinary workers, nursing homes, and also the general public.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
jandro M. Katzin Human parasitic protozoa cause a large number of diseases worldwide and, for some of these diseases, there are no effective treatments to date, and drug resistance has been observed. For these reasons, the discovery of new etiological treatments is necessary. In this sense, parasitic metabolic pathways that are absent in vertebrate hosts would be interesting research candidates for the identification of new drug targets. Most likely due to the protozoa variability, uncertain phylogenetic origin, endosymbiotic events, and evolutionary pressure for adaptation to adverse environments, a surprising variety...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
eet Kaushik Waterborne diseases that originated due to pathogen microorganisms are emerging as a serious global health concern. Therefore, rapid, accurate, and specific detection of these microorganisms (i.e., bacteria, viruses, protozoa, and parasitic pathogens) in water resources has become a requirement of water quality assessment. Significant research has been conducted to develop rapid, efficient, scalable, and affordable sensing techniques to detect biological contaminants. State-of-the-art technology-assisted smart sensors have improved features (high sensitivity and very low detection limit) and can perform in ...
Source: Sensors - Category: Biotechnology Authors: Tags: Review Source Type: research
AbstractA new species,Alexandercestus masoumehae n. sp., is described from the sicklefin lemon shark,Negaprion acutidens (R üppell), from the Iranian coast of the Gulf of Oman. The new species is the third in this genus, all parasitizing species ofNegaprion Whitley. Based on morphological characters and scanning electron microscopy the new species is different from its congeners of in a combination of characters including total length, terminal proglottid length, cirrus sac length, and genital pore position. Compared toAlexandercestus gibsoni Ruhnke&Workman, 2013 andA. manteri Ruhnke&Workman, 2013 the specimen...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
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