Increased extracellular free-water in adult male rats following in utero exposure to maternal immune activation.

CONCLUSION: We identified excess FW across frontal white matter fibers of rats exposed to prenatal immune activation, analogous to our "bedside" observation in FEP patients. Findings from this initial experiment promote use of the MIA model to examine pathological pathways underlying FW alterations observed in patients with schizophrenia. Establishing these mechanisms has important implications for clinical studies, as free-water imaging reflects a feasible biomarker that has so far yielded consistent findings in the early stages of schizophrenia. PMID: 31521731 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31521731?dopt=Abstract

Source: Brain, Behavior, and Immunity - September 11, 2019 Category: Neurology Authors: Di Biase MA, Katabi G, Piontkewitz Y, Cetin-Karayumak S, Weiner I, Pasternak O Tags: Brain Behav Immun Source Type: research