A neglected bronchial foreign body for 23 years.
We report a case of a neglected foreign body present in the bronchus of an adult for 23 years and treated as intermittent asthma. The diagnosis was revealed following the development of severe sepsis of a pulmonary origin. The foreign body was removed by rigid bronchoscopy, antibiotic therapy instituted and pre- and post-interventional respiratory physiotherapy carried out. Satisfactory progress was marked by the complete clearing of pulmonary suppuration, with only a small localized and asymptomatic focus of bronchial dilatation remaining. The persistence of chronic, unexplained respiratory complaints should prompt the use of imaging and endoscopy to exclude an endobronchial cause, especially to consider the possible presence of a previously unknown foreign body. Early diagnosis and intervention can help to avoid potentially serious complications. PMID: 31521433 [PubMed - as supplied by publisher]
We report 13 cases (11 males/2 females) of SPM. The average age was 31 ± 0.85 years. The most common precipitating factor was asthma attack. The onset symptoms were mainly chest pain (11 cases). Synchronous pneumothorax was found in 5 cases and it was bilateral in 2 patients. The evolution was marked by the spontaneous resorption. SMP is an underrecognized cause of chest pain in young adults. Chest radiography is usually sufficient for the diagnosis, and further diagnostic procedures are generally not necessary. The prognosis is often favorable.
Publication date: Available online 14 October 2019Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Huda Badri, Jaclyn A. SmithAbstractCough is mediated by vagal afferent fibres innervating the larynx and proximal airways. Pre-clinical studies suggest that vagal C fibres produce Substance P, one of the tachykinin family of neuropeptides, which has been shown to enhance cough via the neurokinin-1 (NK-1) receptor and studies in animal models have also shown that NK-1 antagonists are effective at blocking induced cough. In the past, tachykinin receptor antagonists have yielded disappointing results in treating asthma...
Conditions: Chronic Obstructive Pulmonary Disease; Asthma; Diabetes Mellitus, Type 2; Heart Failure Intervention: Device: Assessment of Burden of Chronic Conditions (ABCC)-tool Sponsors: Maastricht University; Netherlands Instititute for Health Services Research; TNO; University of Twente Recruiting
Condition: Severe Eosinophilic Asthma Intervention: Sponsor: AstraZeneca Not yet recruiting
Asthma is a heterogeneous syndrome that has been subdivided into physiologic phenotypes and molecular endotypes. The most specific phenotypic manifestation of asthma is indirect airway hyperresponsiveness (AHR), and a prominent molecular endotype is the presence of type 2 inflammation. The underlying basis for type 2 inflammation and its relationship to AHR are incompletely understood. We assessed the expression of type 2 cytokines in the airways of subjects with and without asthma who were extensively characterized for AHR. Using quantitative morphometry of the airway wall, we identified a shift in mast cells from the sub...
Conclusions:The absence of demographic or clinical predictors of OSA supports using general indications for PSG in children with ASD.Citation:Tomkies A, Johnson RF, Shah G, Caraballo M, Evans P, Mitchell RB. Obstructive sleep apnea in children with autism.J Clin Sleep Med. 2019;15(10):1469–1476.
Conditions: Allergy; Respiratory Disease Intervention: Drug: Allergy immunotherapy (AIT) Sponsor: ALK-Abelló A/S Active, not recruiting
Condition: Asthma Intervention: Other: Observation, no intervention Sponsor: Chinese University of Hong Kong Not yet recruiting
Title: A Parent's Guide to Managing Kids' Asthma During the FallCategory: Health NewsCreated: 10/12/2019 12:00:00 AMLast Editorial Review: 10/14/2019 12:00:00 AM
In longitudinal analysis, half of children with severe asthma initially were no longer severe after three years, and asthma severity decreased equally in males and females. Peripheral eosinophilia predicted resolution.