Pulsed reduced dose rate for re-irradiation of recurrent breast cancer

ConclusionsPRDR radiation therapy with capecitabine were well tolerated and effective method for treating patients with recurrent breast cancer. Prospective studies are necessary to compare side effects and efficacy with conventional dose rate re-irradiation, as well as, to evaluate the potential role for capecitabine in the recurrent setting.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Abstract Radiation dermatitis is a common adverse effect of radiotherapy (RT) in breast cancer patients. Although radiation dermatitis is reported by either the clinician or the patient, previous studies have shown disagreement between clinician-reported outcomes (CROs) and patient-reported outcomes (PROs). This review evaluated the extent of discordance between CROs and PROs for radiation dermatitis. Studies reporting both clinician and patient-reported outcomes for external beam RT were eligible. Nine studies met the inclusion criteria for the systematic review, while 8 of these studies were eligible for inclusi...
Source: Breast - Category: Cancer & Oncology Authors: Tags: Breast Source Type: research
Although we report an increased rate of grade (G) 2 or greater radiation dermatitis (RD), predominantly driven by G2 toxicity, we do not describe a doubling in the overall rate of RD seen in patients with breast cancer undergoing adjuvant proton pencil-beam scanning (PBT). We advise counseling patients of the potential for increased dermatologic toxicity, though this should not affect modality selection, considering a very low number of patients experienced G3 to G4 RD.1Although it is notable that this increased toxicity occurs in the absence of bolus, we do not conclude that PBT should be used in lieu of photon radiation ...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research
ConclusionsThese results suggest possible association of these efflux transporters with dermal inflammatory mediators, and such association could be observed in the dermatitis skin.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
Conditions:   Breast Cancer;   Radiodermatitis;   Radiotherapy Side Effect;   Radiation Dermatitis;   Radiation Toxicity;   Radiation Injuries;   Quality of Life;   Breast Neoplasms Intervention:   Device: Photobiomodulation Sponsor:   AC Camargo Cancer Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: IMPT following IBR spared underlying organs and had low rates of acute toxicity. Reconstruction complications are more common in irradiated breasts, and reconstructive outcomes appear comparable with photon literature. Hypofractionation was associated with higher reconstruction failure rates. Further investigation of optimal dose-fractionation after IBR is needed. PMID: 31185327 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
ConclusionsTopical agents for preventive ARD are reported by patients to show different cosmetic properties. Cosmetic properties are important when choosing topical agents for ARD prevention. Recommending those with better cosmetic profiles would improve patient adherence to treatments.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Conclusion: IOERT boost during BCS is a safe treatment option with low acute toxicity. Short-term recurrence rates are comparable to previously published data and emphasize, that IOERT as boost is an effective treatment.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
More News: Breast Cancer | Cancer | Cancer & Oncology | Dermatitis | Dermatology | Gastroschisis Repair | Radiation Therapy | Study | Toxicology | Xeloda