Novel Use of Continuous Positive Airway Pressure Permits Heart- and Lung-Sparing Mediastinal Involved-Site Radiation Therapy for Patient With Hodgkin Lymphoma in Community Clinic When Deep Inspiration Breath-Hold Technique Is Not Available
Publication date: Available online 4 February 2019Source: Practical Radiation OncologyAuthor(s): Whoon Jong Kil (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 17, 2019 Category: Cancer & Oncology Source Type: research

Personalized Treatment for Lacrimal Sac Adenoid Cystic Carcinoma: Case Report and Literature Review
Publication date: Available online 4 February 2019Source: Practical Radiation OncologyAuthor(s): Randy C. Bowen, Huaising C. Ko, Gregory D. Avey, Gregory K. Hartig, Rong Hu, Paul M. Harari, Mark J. Lucarelli (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 15, 2019 Category: Cancer & Oncology Source Type: research

A burnout reduction and wellness strategy: personal financial health for the medical trainee and early career radiation oncologist
Publication date: Available online 7 March 2019Source: Practical Radiation OncologyAuthor(s): Trevor J. Royce, Kathleen T. Davenport, James M. DahleAbstractPhysician burnout is reported in more than one out of every two practicing clinicians and is just as prevalent in training physicians. Burnout severity is also associated with increasing levels of financial debt. Medical professionals are notable for their high and rising levels of debt – despite this, financial literacy is poor among physicians and financial education is largely absent from medical education. Radiation oncologists (RO) are no different in this re...
Source: Practical Radiation Oncology - March 9, 2019 Category: Cancer & Oncology Source Type: research

Precision of 2 Low-dose Abdomen/Pelvis Cone Beam Computed Tomography Protocols for Alignment to Bone and Soft Tissue in Pediatric Patients Receiving Image Guided Radiation Therapy
ConclusionsClinics treating pediatric patients should consider implementing a protocol mirroring LD-CBCT2 for abdomen and pelvis IGRT bone alignment. Further evaluation of the precision of LD-CBCTs for soft-tissue alignment is necessary. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 5, 2019 Category: Cancer & Oncology Source Type: research

Appreciation of 2018 peer reviewers for Practical Radiation Oncology
Publication date: Available online 5 March 2019Source: Practical Radiation OncologyAuthor(s): W.Robert Lee, Robert Amdur, Megan E. Daly, Prajnan Das, Suzanne Evans, Jeff Michalski, Todd Pawlicki (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 5, 2019 Category: Cancer & Oncology Source Type: research

Dose Constraint Model to Predict Neuroendocrine Dysfunction in Young Patients with Brain Tumours: Data from a Prospective Study
ConclusionsOur prospective longitudinal study demonstrates feasibility of HPA avoidance using modern high-precision conformal RT techniques and correlates HPA dosimetry with neuroendocrine dysfunction. We suggest restricting HPA dose to
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Durable improvement in patient safety culture over 5 years with use of high-volume incident learning system
Publication date: Available online 28 February 2019Source: Practical Radiation OncologyAuthor(s): Pehr E. Hartvigson, Aaron S. Kusano, Matthew J. Nyflot, Loucille Jordan, Tru-Khang Dinh, Patricia A. Sponseller, Ashlee Schindler, Gabrielle M. Kane, Eric C. FordAbstractPurposeIncident learning systems (ILS) require substantial time and effort to maintain, risking staff burnout and ILS disuse. Here we assess the durability of ILS-associated safety culture improvements and ILS engagement at five years.Methods and materialsA validated survey assessing safety culture was administered to all staff of an academic radiation oncolog...
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Automated closed- and open-loop validation of knowledge-based planning routines across multiple disease sites
Publication date: Available online 1 March 2019Source: Practical Radiation OncologyAuthor(s): Robert Kaderka, Robert C. Mundt, Nan Li, Benjamin Ziemer, Victoria N. Bry, Mariel Cornell, Kevin L. MooreAbstractPurposeKnowledge-based planning (KBP) clinical implementation necessitates significant up-front effort even within a single disease site. The purpose of this study was to demonstrate an efficient method for clinicians to (a) assess the non-inferiority of KBP across multiple disease sites and (b) estimate any systematic dosimetric differences post-implementation. We sought to establish these endpoints in a plurality of p...
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Masthead/Sub page
Publication date: March–April 2019Source: Practical Radiation Oncology, Volume 9, Issue 2Author(s): (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: March–April 2019Source: Practical Radiation Oncology, Volume 9, Issue 2Author(s): (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Table of Contents
Publication date: March–April 2019Source: Practical Radiation Oncology, Volume 9, Issue 2Author(s): (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Letter to the Editor Regarding: Prospective Comparison of Toxicity and Cosmetic Outcome After Accelerated Partial Breast Irradiation with Conformal External Beam Radiotherapy or Single-Entry Multilumen Intracavitary Brachytherapy
Publication date: March–April 2019Source: Practical Radiation Oncology, Volume 9, Issue 2Author(s): John M. David, Mitchell Kamrava (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Is It Necessary to Test Oropharyngeal Cancer for Both p16 and Human Papillomavirus?
Publication date: March–April 2019Source: Practical Radiation Oncology, Volume 9, Issue 2Author(s): Rohan Deraniyagala (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Standardizing Normal Tissue Contouring for Radiation Therapy Treatment Planning: An ASTRO Consensus Paper
ConclusionsUsing this paper in conjunction with resources that define tissue parameters and published dose constraints will enable practices to develop a consistent approach to normal tissue evaluation and dose documentation. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Lung Adenocarcinoma Metastasis to the Prostate: A Case Report
Publication date: March–April 2019Source: Practical Radiation Oncology, Volume 9, Issue 2Author(s): Natasha Gilmour, Wambaka Ange Mampuya, Raphael Jumeau, Nicolas Dattner, Mahmut Ozsahin (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Analysis of Local Control and Pain Control After Spine Stereotactic Radiosurgery Reveals Inferior Outcomes for Hepatocellular Carcinoma Compared With Other Radioresistant Histologies
ConclusionsCompared with other radioresistant histologies, HCC has inferior LC and pain relief after SRS. Whether HCC may benefit from further dose escalation or combined treatment with new therapies is an area of future research. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Effect of Tumor Location and Dosimetric Predictors for Chest Wall Toxicity in Single-Fraction Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer
ConclusionsThe rate of CWT with SF-SBRT is similar to the rates published for fractionated SBRT, with most CWT being low grade. Tumor location relative to the chest wall is not a contraindication to SF-SBRT, but the rates increase significantly with abutment. Rib D1cc and chest wall D1cc and D5cc may be used as predictors of CWT. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Predictive models to determine clinically relevant deviations in delivered dose for head and neck cancer
ConclusionsA mid-treatment threshold deviation was determined to predict the need to replan for the submandibular glands by fraction 15 of 30-35 total fractions of RT. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Important technical considerations for implementing the ASTRO/ASCO/AUA prostate cancer hypofractionated radiation guideline
Publication date: Available online 2 March 2019Source: Practical Radiation OncologyAuthor(s): Michael J. LaRiviere, Timothy C. Zhu, John P. Christodouleas (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Volumetric modulated arc therapy and 3-dimensional printed bolus in the treatment of refractory primary cutaneous gamma delta lymphoma of the bilateral legs
Publication date: Available online 2 March 2019Source: Practical Radiation OncologyAuthor(s): Jean-Pierre Obeid, Paulina M. Gutkin, Jonathan Lewis, Lawrie Skinner, Erica B. Wang, Michael S. Khodadoust, Youn H. Kim, Wen-Kai Weng, Richard T. Hoppe, Susan M. HinikerAbstractPatients with extensive dermal and subcutaneous disease present a technical challenge for treatment with radiation therapy (RT). Volumetric arc therapy (VMAT) can effectively treat disease on circumferential surfaces while minimizing dose to the core structures. However, treatment of extensive areas of the bilateral lower extremities with this technique has...
Source: Practical Radiation Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Radiation Oncologist Characteristics and their Association with Outcomes in Patients with Head and Neck Cancer
ConclusionsROs who were recently trained and had a high treatment volume are associated with poorer outcomes among patients with HNC who receive IMRT treatment. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 28, 2019 Category: Cancer & Oncology Source Type: research

Advances in oncology: Implications for patients and practitioners and Hope for Oncologists
Publication date: Available online 27 February 2019Source: Practical Radiation OncologyAuthor(s): Laura Freedman (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 28, 2019 Category: Cancer & Oncology Source Type: research

NRG Oncology/RTOG 0438: A Phase I Trial of Highly Conformal Radiation Therapy for Liver Metastases
ConclusionsTreatment of liver metastases with 50 Gy in 10 fractions was feasible and safe in a multi-institutional setting. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 28, 2019 Category: Cancer & Oncology Source Type: research

Hemorrhage from Ascending Colon and Gluteal Muscle Associated with Sorafenib and Radiotherapy: Radiation Dose Distribution Corresponded with Colonoscopy Findings and Computed Tomography Images
ConclusionsThe administration of sorafenib during RT can lead to intestinal and intramuscular bleeding. Therefore, the risk of bleeding from organs exposed to RT must be taken into account when RT and VEGFR-TKI administration occurs simultaneously or in succession. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 28, 2019 Category: Cancer & Oncology Source Type: research

Neoadjuvant Chemoradiotherapy Followed by Extrafascial Hysterectomy in Locally Advanced Type II Endometrial Cancer Clinically Extending to Cervix
ConclusionsNeoadjuvant chemoradiotherapy effectively downstages the majority of locally-advanced type II endometrial cancers, thereby increasing the likelihood of achieving complete resection with negative margins. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 23, 2019 Category: Cancer & Oncology Source Type: research

Prospective study to quantify the expansion volumes around the involved pelvic lymph nodes for planning Simultaneous Integrated Boost in patients of cervical cancer undergoing pelvic Intensity Modulated Radiotherapy
ConclusionsAn isotropic expansion margin of 3mm for ITV and 5mm for PTV is necessary for enlarged pelvic lymph nodes while planning SIB-IMRT for cervical cancer. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 23, 2019 Category: Cancer & Oncology Source Type: research

Dose Selection for Multiple Myeloma in Modern Era
Publication date: Available online 22 February 2019Source: Practical Radiation OncologyAuthor(s): Shutao Wang, Lucas Resende Salgado, Ava Adler, Sanders Chang, Meng Ru, Erin Moshier, Kavita Dharmarajan, Hearn Jay Cho, Richard L. BakstAbstractIntroductionThe management of multiple myeloma (MM) has evolved in the past twenty years secondary to novel biological therapeutics. Radiotherapy remains an important intervention in the management of painful lytic bone lesions. However, the currently used radiotherapy regimens were developed in the pre-biological therapy era. The goal of this study is to assess the effects of dose and...
Source: Practical Radiation Oncology - February 23, 2019 Category: Cancer & Oncology Source Type: research

Clinical Outcomes of Patients with Recurrent Lung Cancer Reirradiated with Proton Therapy on the Proton Collaborative Group and University of Florida Proton Therapy Institute Prospective Registry Studies
ConclusionThis is the largest series to date of PBT reirradiation for recurrent lung cancer, showing that reirradiation with PBT is well tolerated with acceptable toxicity and encouraging efficacy. ECOG performance status was associated with OS and PFS. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 23, 2019 Category: Cancer & Oncology Source Type: research

A Population-Based Study of Palliative Radiation Therapy for Bone Metastases in Patients Dying of Prostate Cancer
ConclusionsPRTB is only used in a minority of patients dying of PCa. The majority who die of PCa after PRTB do so within a year of their first course. The use of multifractionation was common in the last 4 weeks of life. Survival after first PRTB increased minimally over time, and additional research is required to identify its association with recent changes in practice. The referral rate and PRTB utilization rate differ between rural and nonrural locations, underlying the importance of accessibility and referral for utilization of PRTB. Investigating other barriers and ensuring equitable access to radiation are need...
Source: Practical Radiation Oncology - February 22, 2019 Category: Cancer & Oncology Source Type: research

Patient Reported Outcomes and Cosmesis in a Feasibility Study of 4D Simulated Image Guided Accelerated Partial Breast Irradiation (APBI)
Publication date: Available online 20 February 2019Source: Practical Radiation OncologyAuthor(s): Elham Rahimy, Joanne Weidhaas, Wei Wei, Donald Lannin, Nina Horowitz, Susan Higgins, Lynn D. Wilson, Christin Knowlton, Meena S. Moran, Melissa Rasar Young, Brigid Killelea, Anees Chagpar, Debra Nana Yeboa, Dan Zelterman, Suzanne EvansAbstractPurposeThree-dimensional Conformal Accelerated Partial Breast Irradiation (APBI) is a treatment option for well selected women with breast cancer, despite reports of adverse cosmetic outcome with this technique. It is postulated that dose-volume relationships may be responsible for this p...
Source: Practical Radiation Oncology - February 20, 2019 Category: Cancer & Oncology Source Type: research

Patterns of failure among low-grade glioma patients treated with proton radiotherapy
Publication date: Available online 18 February 2019Source: Practical Radiation OncologyAuthor(s): Sophia C. Kamran, Michael Dworkin, Andrzej Niemierko, Marc Bussiere, Kevin S. Oh, Jay S. Loeffler, Helen A. ShihAbstractPurposeProton treatment may be a useful radiation therapy (RT) modality for long-term surviving glioma patients to reduce normal tissue toxicities. Photon studies demonstrate that most low-grade glioma (LGG) failures occur within the radiation field, supporting the use of more conformal treatment plans, yet it is unclear whether this can be translated to proton RT (PRT). Our objective is to examine our instit...
Source: Practical Radiation Oncology - February 18, 2019 Category: Cancer & Oncology Source Type: research

Lessons Learned from First in Human Low-Field MRI-Guided Radiation Therapy of the Heart in the Presence of an Implantable Cardiac Defibrillator
Publication date: Available online 18 February 2019Source: Practical Radiation OncologyAuthor(s): H. Michael Gach, Olga L. Green, Phillip S. Cuculich, Erin J. Wittland, Areti Marko, Molly E. Luchtefeld, Jill M. Entwistle, Deshan Yang, David J. Wilber, Sasa Mutic, Clifford G. RobinsonAbstractMagnetic resonance imaging guided radiation therapy (MR-IGRT) is reported for the first time in a patient with an implantable cardioverter defibrillator (ICD) and a cardiac fibroma in the left ventricle. Stereotactic body radiation therapy (SBRT) was delivered in five fractions at a dose of 700 cGy/fraction using a 0.35 T MRI-Linac with...
Source: Practical Radiation Oncology - February 18, 2019 Category: Cancer & Oncology Source Type: research

Complementary relation between the improvement of dose delivery technique and PTV margin reduction in dose-escalated radiation therapy for prostate cancer
ConclusionsThe complementary relation between the introduction of IMRT and PTV margin reduction was proven. We found that both approaches need to be implemented to safely deliver a curative dose in dose-escalating prostate radiation therapy. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 15, 2019 Category: Cancer & Oncology Source Type: research

Erlotinib-Associated Rash Exacerbated by Whole-Brain Radiation Therapy: A Patient's Case Report
Publication date: Available online 13 February 2019Source: Practical Radiation OncologyAuthor(s): Alexander K. Erikson, Nathan Y. Yu, Janina T. Sheedy, Staci N. Shoudis, Harshita R. Paripati, Terence T. Sio (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 13, 2019 Category: Cancer & Oncology Source Type: research

Low-Dose Radiation Therapy is an Effective Treatment for Refractory Postoperative Chylous Ascites: A Case Report
ConclusionsLD-RT for refractory postoperative chylous ascites is a safe and reasonable option that can provide temporary relief in addition to other conservative methods. This is the first reported case of refractory chylous ascites in the United States that was successfully treated with LD-RT. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 12, 2019 Category: Cancer & Oncology Source Type: research

The Impact of Low-Dose Cranial Boost on the Long-Term Outcomes of Adult Patients with High-Risk Acute Lymphoblastic Leukemia Undergoing Total Body Irradiation and Allogeneic Hematopoietic Stem Cell Transplantation
ConclusionsAdult patients with high-risk, CNS-negative ALL were found to have a statistically significant improvement in CNS relapse-free survival and a trend toward improved progression-free survival with the inclusion of a cranial boost with TBI pretransplant conditioning. Our data indicate that further investigation into the use of cranial boost in this patient population is warranted. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 8, 2019 Category: Cancer & Oncology Source Type: research

Patterns of Relapse After Salvage Autologous Stem Cell Transplant for Hodgkin's Lymphoma: Should Sites of Relapse Relative to Initially Involved Sites Be Used to Guide Indications for Peri-Transplant Radiation Therapy
Publication date: Available online 21 December 2018Source: Practical Radiation OncologyAuthor(s): Joshua C. Farris, Alex Ritter, Michael D. Craig, Nilay Shah, Lauren Veltri, Abraham S. Kanate, Kelly Ross, John A. VargoAbstractPurposeWe aimed to assess patterns of relapse in patients undergoing salvage autologous stem cell transplant (ASCT) for relapsed Hodgkin lymphoma in the modern era with the hypothesis that patients who suffer a relapse at initially involved sites are at increased risks of relapse post-ASCT that may help guide the application of peri-transplant radiation therapy.Methods and MaterialsA retrospective rev...
Source: Practical Radiation Oncology - February 8, 2019 Category: Cancer & Oncology Source Type: research

Robustness Analysis for External Beam Radiation Therapy Treatment Plans: Describing Uncertainty Scenarios and Reporting Their Dosimetric Consequences
ConclusionThe robustness analysis approach described here is presented to promote reliable plan evaluation and dose reporting, particularly during clinical trials conducted across institutions and treatment modalities. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 7, 2019 Category: Cancer & Oncology Source Type: research

Novel Use of Continuous Positive Airway Pressure (CPAP) Permits Heart and Lung Sparing Mediastinal Involved-Site Radiotherapy for patient with Hodgkin Lymphoma in Community clinic when Deep Inspiration Breath Hold technique was not available
Publication date: Available online 4 February 2019Source: Practical Radiation OncologyAuthor(s): Whoon Jong Kil (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 5, 2019 Category: Cancer & Oncology Source Type: research

Hypopituitarism following Cranial Irradiation for Meningiomas: A single-institution experience
Publication date: Available online 4 February 2019Source: Practical Radiation OncologyAuthor(s): Nayan Lamba, Marc R. Bussiere, Andrzej Niemierko, Parisa Abedi, Barbara C. Fullerton, Jay S. Loeffler, Kevin S. Oh, Lisa B. Nachtigall, Helen A. ShihAbstractBackgroundPatients undergoing cranial irradiation are at high risk for development of subsequent pituitary deficiencies. Patients with meningiomas can expect to live many years following treatment and are therefore particularly vulnerable to long-term sequalae of radiation therapy (RT). The purpose of this study was to determine the rates and timing of onset of pituitary dy...
Source: Practical Radiation Oncology - February 5, 2019 Category: Cancer & Oncology Source Type: research

Personalized Treatment for Lacrimal Sac Adenoid Cystic Carcinoma - Case Report and Literature Review
Publication date: Available online 4 February 2019Source: Practical Radiation OncologyAuthor(s): Randy C. Bowen, Huaising C. Ko, Gregory D. Avey, Gregory K. Hartig, Rong Hu, Paul M. Harari, Mark J. Lucarelli (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 5, 2019 Category: Cancer & Oncology Source Type: research

Characterization of Chest Wall Toxicity during Long Term Follow Up after Thoracic Stereotactic Body Radiotherapy
Publication date: Available online 4 February 2019Source: Practical Radiation OncologyAuthor(s): Christopher Chipko, Julius Ojwang, Leila Rezai Gharai, Xiaoyan Deng, Nitai Mukhopadhyay, Elisabeth WeissAbstractPurposeChest wall (CW) pain and rib fractures are frequently diagnosed following stereotactic body radiotherapy (SBRT) for malignant lung tumors. We hypothesize that multiple risk factors including bone mineral density (BMD) are associated with CW toxicity and that CW pain and rib fractures often evolve into chronic clinical problems.Methods118 lung tumors treated with SBRT in 100 patients with a minimum follow up of ...
Source: Practical Radiation Oncology - February 5, 2019 Category: Cancer & Oncology Source Type: research

Delineation of a Cardiac Planning Organ-At-Risk Volume Using Real-Time Magnetic Resonance Imaging for Cardiac Protection in Thoracic and Breast Radiation Therapy
ConclusionsWe implemented scale-invariant feature transformation-based motion tracking for analysis of the cardiac cine MRI scans to quantify motion and create cohort-based cardiac PRVs to improve cardioprotection in breast and thoracic radiation. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - February 3, 2019 Category: Cancer & Oncology Source Type: research

Liza
Publication date: Available online 29 January 2019Source: Practical Radiation OncologyAuthor(s): Ronald D. Ennis (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - January 30, 2019 Category: Cancer & Oncology Source Type: research

Recognition of Tumor Invasion of a Pancreatic Head Biliary Stent during Stereotactic Body Radiation Therapy
Publication date: Available online 29 January 2019Source: Practical Radiation OncologyAuthor(s): Ethan Song, Daniel Segarra, Kujtim Latifi, Susan Leuthold, Dalila Belinc, Luis Pena, Mokenge Malafa, Jessica M. Frakes, Sarah E. HoffeAbstractA radiation oncologist’s recognition of the typical course of anticipated side effects during pancreatic stereotactic body radiation therapy (SBRT) is important. Given the excellent rates of toleration, development of unanticipated pain calls for prompt evaluation. In this article, we report the case of a 51-year-old male with locally advanced pancreatic cancer experiencing focal ri...
Source: Practical Radiation Oncology - January 30, 2019 Category: Cancer & Oncology Source Type: research

Clinical intensity-modulated proton therapy for Hodgkin lymphoma: which patients benefit the most?
ConclusionsPBS gives good target coverage and local control whilst providing reductions in radiation dose to OAR for individuals receiving RT for HL compared to advanced photon RT. Our findings highlight certain groups of patients who would be expected to gain more dosimetric benefit from PBS. These findings facilitate the selection of patients who should be considered a priority for PT. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - January 30, 2019 Category: Cancer & Oncology Source Type: research

Rainbow IMRT and Volumetric Imaging for Anterior Mesenteric Targets
We report the case of a highly-mobile mesenteric mass which required adaptive planning from a traditional “butterfly” intensity modulated radiation therapy (IMRT) plan to an anterior “rainbow” beam arrangement to permit shifting of the isocenter without compromising target coverage or increasing dose to organs-at-risk. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - January 30, 2019 Category: Cancer & Oncology Source Type: research

Reply to the Letter to the Editor “Regarding: Prospective Comparison of Toxicity and Cosmetic Outcome After Accelerated Partial Breast Irradiation with Conformal External Beam Radiotherapy or Single-Entry Multilumen Intracavitary Brachytherapy”
Publication date: Available online 30 January 2019Source: Practical Radiation OncologyAuthor(s): Shane R. Stecklein, Elizabeth S. Bloom (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - January 30, 2019 Category: Cancer & Oncology Source Type: research

Multi-Institutional Validation of a Knowledge-Based Planning Model for Patients Enrolled in RTOG 0617: Implications for Plan Quality Controls in Cooperative Group Trials
ConclusionsA single-institution KBP model can be applied as a QC tool for multi-institutional clinical trials to improve overall plan quality and provide decision-support to determine the need for anatomy-based dosimetric trade-offs. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - January 26, 2019 Category: Cancer & Oncology Source Type: research

Cardiac structure doses in women irradiated for breast cancer in the past and their use in epidemiological studies
Publication date: Available online 26 January 2019Source: Practical Radiation OncologyAuthor(s): Frances K. Duane, Paul McGale, Dorthe Brønnum, David J. Cutter, Sarah C. Darby, Marianne Ewertz, Sara Hackett, Per Hall, Ebbe L. Lorenzen, Kazem Rahimi, Zhe Wang, Samantha Warren, Carolyn W. TaylorAbstractBackgroundand Purpose: Incidental cardiac exposure during radiotherapy may cause heart disease. Dose-response relationships for cardiac structures (segments) may show which are most sensitive to radiation. As radiation-related cardiac injury can take years to develop, such studies inevitably need involve women treated u...
Source: Practical Radiation Oncology - January 26, 2019 Category: Cancer & Oncology Source Type: research