New perspectives in Aspiration Community Acquired Pneumonia.

New perspectives in Aspiration Community Acquired Pneumonia. Expert Rev Clin Pharmacol. 2019 Sep 13;: Authors: Rodriguez AE, Restrepo MI Abstract INTRODUCTION: Aspiration pneumonia is a subclass of community-acquired pneumonia that is expected to have an increasing contribution in mortality and morbidity, particularly in the elderly population over the next coming decades. While studies have revealed significant progress in identifying risk factors for aspiration pneumonia, the clinical presentation and diagnosis remains challenging to healthcare providers. Areas Covered: We conducted a broad literature review using the MeSH heading in PubMed/MEDLINE of "aspiration pneumonia" from January 1970 to July 2019. The understanding of the microbiology of aspiration pneumonia has evolved from a possible shift in the causative organisms away from anaerobes to traditional community-acquired pneumonia organisms. The importance of this shift is not yet known, but it has questioned the pathogenic role of anaerobes, appropriate anaerobic testing and the role of these pathogens in the pulmonary microbiome in patients with pneumonia. The identification of risk factors led to strategies to prevent or minimize the risk of aspiration pneumonia with moderate success. Expert Opinion: Our expert opinion is that further research is needed to determine the role of the microbiome with aspiration pneumonia and patient risk factors. There is also a great need to develop c...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research

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Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
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Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
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Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Once considered a safer alternative to cigarettes, radiologists are now drawing connections between vaping and lung injury patterns, according to a  studypublished this month in theAmerican Journal of Roentgenology. This isn ’t the first time that radiologists are voicing concerns about the adverse effects of e-cigarettes. A magnetic resonance imaging (MRI) studypublished in August showed that a single session of vaping causes reduced blood flow and damaged vascular reactivity in the femoral artery. The researchers also found that the vaping solution consists of potentially harmful chemicals that when ...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Authors: Schöll N, Rohde GGU Abstract Pneumonia belongs to the most frequent and most deadly infectious diseases worldwide. It represents an increasing problem for the aging population. The incidence and mortality rises with every decade. The clinical presentation of pneumonia differs between elderly and younger patients. Multiple factors including functional status (self-dependency and immobilization), comorbidities, immunosenescence, nutritional status, swallowing disorders have to be accounted for. Pneumonia in the elderly has to be differentiated from nursing home acquired pneumonia. Diagnosis of pneumonia...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
In this review, we report the available data regarding efficacy, safety and pharmacokinetics of colistin in the treatment of multidrug-resistant Gram-negative bacteria in neonates and infants. Seventeen clinical studies, involving 312 patients, and 3 pharmacokinetics studies were identified. Blood stream infection was the most common source of infection, followed by pneumonia and meningitis/ventriculitis. In most cases, colistin was administered in association with other antibiotics. The most common route of administration was intravenous, with colistimethate doses ranging from 25,000 to 225,000 IU/kg/day divided into 2 or...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research
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Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 17 October 2019Source: The Lancet Respiratory MedicineAuthor(s): The Lancet Respiratory Medicine
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
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Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Data Health Tech Health Technology AI Jared Dunnmon Luke Oakden-Rayner machine learning Source Type: blogs
Abstract Humoral immunological defects are frequent and important causes of hypogammaglobulinemia, leading to recurrent infections, autoimmunity, allergies, and neoplasias. Usually, its onset occurs in childhood or during the second and third decades of life; however, the diagnosis is made, on average, 6 to 7 years afterwards. As a consequence, antibody defects can lead to sequelae. Here we describe the clinical-laboratory characteristics, treatment, and prognoses of patients with hypogammaglobulinemia. An observational, cross-sectional, and retrospective study of patients attending the recently established outpat...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
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