Ulmus minor bark hydro-alcoholic extract ameliorates histological parameters and testosterone level in an experimental model of PCOS rats.

Ulmus minor bark hydro-alcoholic extract ameliorates histological parameters and testosterone level in an experimental model of PCOS rats. Endocr Regul. 2019 Jul 01;53(3):146-153 Authors: Hoseinpour MJ, Ghanbari A, Azad N, Zare A, Abdi S, Sajadi E, Abbaszadeh HA, Farahani RM, Abdollahifar MA Abstract OBJECTIVE: Polycystic ovary syndrome (PCOS) is a common and multifactorial disease associated with female factor infertility. Ulmus minor bark (UMB) is one of the medicinal plants used in Persian folklore as a fertility enhancer. In the current study, we aimed to elucidate the effect of UMB hydro-alcoholic extract on histological parameters and testosterone condition in an experimental model of PCOS rats. METHODS: Thirty female rats were randomly divided into five groups: (1) control, (2) vehicle, (3) PCOS/50 mg [6 mg/kg dehydroepiandrosterone (DHEA) + 50 mg/kg UMB hydro-alcoholic extract], (4) PCOS/150 mg (6 mg/kg DHEA + 150 mg/kg UMB hydro-alcoholic extract), and (5) PCOS (6 mg/kg DHEA). All interventions were performed for 21 days. Afterwards, stereological analysis was done for determination of ovarian volume and follicle number. The serum level of testosterone was measured by ELISA kit. RESULTS: UMB hydro-alcoholic extract improved the total number of the corpus luteum in the treatment groups when compared to the PCOS group (p
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research

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Publication date: February 2020Source: Journal of Catalysis, Volume 382Author(s): Nirala Singh, Udishnu Sanyal, Griffin Ruehl, Kelsey A. Stoerzinger, Oliver Y. Gutiérrez, Donald M. Camaioni, John L. Fulton, Johannes A. Lercher, Charles T. CampbellAbstractThe mechanisms of aqueous-phase thermal catalytic hydrogenation (TCH) and electrocatalytic hydrogenation (ECH) of organic molecules over Pt group metals are not as well-understood as gas-phase thermal catalytic hydrogenation. In gas-phase, the reactions generally occur via a Langmuir-Hinshelwood mechanism with adsorbed hydrogen adding to adsorbed organics. Here, we ...
Source: Journal of Catalysis - Category: Chemistry Source Type: research
As the prevalence of type 1 and type 2 diabetes increases and population-level patterns of alcohol and illicit drug use evolve, clinicians will continue to encounter people with diabetes whose substance use is affecting health outcomes. Substance use contr...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Contributors : Muralidhara R Maradana ; Brendan J O'Sullivan ; Ranjeny ThomasSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNon-alcoholic fatty liver disease (NAFLD) is a common complication of obesity, where insulin resistance and hepatocyte fat deposition may progress to steatohepatitis (NASH) and fibrosis/ cirrhosis. NASH has no approved treatment. Consequent upon hepatic fat deposition, NF- κB activation in hepatic myeloid cells mediates inflammation and NASH progression. We delivered micro-doses of liposome-encapsulated lipophilic NF-κB inhibitors, curcumin or 1,25-d...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Besides ageing, a number of non-modifiable lifestyle-related factors, as smoking, elevated consumption of caffeine and alcohol, stress, agonist sports, chronic exposure to environmental pollutants, and other nutritional habits exert a negative impact on women’s fertility. In particular, metabolic disorders including diabetes, obesity, and hyperlipidemia commonly associated to hypercaloric diets are suspected to promote infertility in women either by direct damage to oocyte health and differentiation, or by indirect interference with the pituitary-hypothalamic axis, resulting in dysfunctional oogenesis. Obese women sh...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
AbstractSTUDY QUESTIONIs maternal polycystic ovarian syndrome (PCOS) associated with developmental delays in offspring?SUMMARY ANSWEROffspring of mothers with PCOS were at higher risk of failure on the Ages and Stages Questionnaire (ASQ).WHAT IS KNOWN ALREADYThere is growing evidence that offspring of mothers with PCOS may be at higher risk for developmental disorders due to potential exposure to hyperandrogenism and insulin resistance. Few studies exist regarding maternal PCOS and early childhood development in the USA.STUDY DESIGN, SIZE, DURATIONThe Upstate KIDS Study is a population-based prospective cohort study of inf...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Infertile women are often so desperate to conceive that they are prepared to make drastic dietary changes, including cutting all carbs, which can wreck havoc on the body, a UK fertility expert said.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Abstract We investigated the prevalence of smoking and factors associated with smoking in infertile Korean women. Smoking status, education, occupation, personal habits, past medical history, current illness, stress level, and menstrual characteristics were collected from self-report questionnaires. The Beck Depression Inventory (BDI) was used to assess the degree of depression. Data on the causes of infertility and levels of six reproductive hormones were collected from medical records. Among 785 women less than 42 years of age, the prevalence of current, secondhand, past, and never smokers were 12.7%, 45.7%, 0.9...
Source: J Korean Med Sci - Category: Journals (General) Authors: Tags: J Korean Med Sci Source Type: research
DiscussionPolycystic ovary syndrome (PCOS) affects 6-8% of reproductive-age women making it the most common endocrinopathy in this age group. There is no consensus on the specific diagnostic criteria for PCOS in adolescents as many of the characteristics overlap with normal adolescent physiology. However, patients should have evidence of hyperandrogenism, oligo- or amenorrhea, and potentially polycystic ovaries. PCOS has a genetic component although a specific gene has not been identified. Incidence of PCOS is 20-40% for a woman with a family history. Hyperandrogenism Androgen levels change during puberty therefore actual ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Polycystic ovary syndrome represents 80% of anovulatory infertility cases. Treatment initially includes preconception guidelines, such as lifestyle changes (weight loss), folic acid therapy to prevent the risk of fetal neural tube defects and halting the consumption of tobacco and alcohol. The first-line pharmacological treatment for inducing ovulation consists of a clomiphene citrate treatment for timed intercourse. The second-line pharmacological treatment includes the administration of exogenous gonadotropins or laparoscopic ovarian surgery (ovarian drilling). Ovulation induction using clomiphene citrate or gonadotropin...
Source: Clinics - Category: Journals (General) Source Type: research
How many times can you begin again? That's what I asked myself as I entered the Hospital for Special Surgery, just three weeks after my first lumbar spine epidural steroid injection and SI joint procedure. I was late. I spent two hours stuck in traffic during my drive from New Jersey to New York. So I was frazzled and my thoughts were scattered when I arrived. Yet, that question, can I start over again after another procedure rattled around in my head. My entire adulthood has been a long and winding road, at least medically. At 17, a sparse menstrual cycle, joint pain and spontaneous fever left doctors scratching their he...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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