GSE137328 MCPyV targets NDRG1 to promote cellular proliferation

Contributors : Purnima Gupta ; Naveed Shahzad ; Alexis Robitaille ; Hector Hernandez-Vargas ; Geoffroy Durand ; Florence Le Calvez-Kelm ; Tarik Gheit ; Rosita Accardi ; Massimo TommasinoSeries Type : Expression profiling by arrayOrganism : Homo sapiensMerkel cell polyomavirus (MCPyV) is the first human polyomavirus etiologically associated with Merkel cell carcinoma (MCC), a rare and aggressive form of skin cancer. Similar to other polyomaviruses, MCPyV encodes early T antigen genes, a viral oncogene required for MCC tumor growth. To identify the unique oncogenic properties of MCPyV, we analysed the gene expression profiles in human spontaneously immortalized keratinocytes (NIKs) expressing the early genes from five distinct human polyomaviruses (PyVs), including MCPyV. A comparison of the gene expression profiles revealed 28 genes specifically deregulated by MCPyV.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research