Risk factors for posttraumatic stress disorder: an umbrella review of systematic reviews and meta-analyses

Publication date: Available online 11 September 2019Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Miquel Tortella-Feliu, Miquel A. Fullana, Ana Pérez-Vigil, Xavier Torres, Jacobo Chamorro, Sergio A. Littarelli, Aleix Solanes, Valentina Ramella-Cravaro, Ana Vilar, José A. González-Parra, Raül Andero, Prof Abraham Reichenberg, Prof David Mataix-Cols, Eduard Vieta, Paolo Fusar-Poli, Prof John P.A. Ioannidis, Prof Murray B. Stein, Joaquim Radua, Lorena Fernández de la CruzAbstractApproximately one third of individuals who experience a severe traumatic event will develop posttraumatic stress disorder (PTSD). It is crucial to identify what factors may be associated with increased or decreased risk for PTSD. We conducted an umbrella review of systematic reviews and meta-analyses of risk/protective factors for PTSD and assessed and graded the evidence of the association between each factor and PTSD. Thirty-three systematic reviews and meta-analyses were included and 130 potential risk factors were identified. Of those, 57 showed a significant association with PTSD. Being female or being indigenous people of the Americas, among the sociodemographic factors; history of physical disease and family history of psychiatric disorder, among the pretrauma factors; and cumulative exposure to potentially traumatic experiences, trauma severity, and being trapped during an earthquake, among the peritrauma factors, showed convincing or highly suggestive evidence of an association wit...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research