Allosteric inhibition of HIV-1 integrase activity.

Allosteric inhibition of HIV-1 integrase activity. Curr Opin Chem Biol. 2013 May 3; Authors: Engelman A, Kessl JJ, Kvaratskhelia M Abstract HIV-1 integrase is an important therapeutic target in the fight against HIV/AIDS. Integrase strand transfer inhibitors (INSTIs), which target the enzyme active site, have witnessed clinical success over the past 5 years, but the generation of drug resistance poses challenges to INSTI-based therapies moving forward. Integrase is a dynamic protein, and its ordered multimerization is critical to enzyme activity. The integrase tetramer, bound to viral DNA, interacts with host LEDGF/p75 protein to tether integration to active genes. Allosteric integrase inhibitors (ALLINIs) that compete with LEDGF/p75 for binding to integrase disrupt integrase assembly with viral DNA and allosterically inhibit enzyme function. ALLINIs display steep dose response curves and synergize with INSTIs ex vivo, highlighting this novel inhibitor class for clinical development. PMID: 23647983 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research

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CONCLUSIONS: This report demonstrates that the streamlined, algorithmic approach effectively identified HIV infections in this large cluster-randomized trial. Longitudinal HIV testing (all participants, all visits) and quality control testing provided useful data on the frequency of errors and provided more accurate data for HIV incidence estimates. PMID: 32072743 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
Office of AIDS Research Advisory Council (OARAC) will include the OAR Director ’ s Report; updates from the DHHS HIV/AIDS Treatment and Prevention Guidelines; updates from NIH HIV/AIDS Advisory Councils and panel discussion with EHE leadership.For more information go tohttps://www.oar.nih.gov/hiv-policy-and-research/oaracAir date: 2/27/2020 8:30:00 AM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Compared to those without the AIDS-causing virus, people with HIV had a 34% higher rate of COPD and were diagnosed with the lung disease about 12 years earlier -- average age 50 versus 62, the investigators found.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Authors: Vardell E Abstract The Global Health Observatory Data Repository is the publicly available interface for the World Health Organization's health-related statistics for the 194 countries that are Member States. It includes statistics for over 1,000 indicators including mortality, child nutrition, maternal health, HIV/AIDS, environmental health, equity, and more. This overview explains the variety of ways that users can access and browse WHO's health-related statistics. PMID: 32069199 [PubMed - in process]
Source: Medical Reference Services Quarterly - Category: Databases & Libraries Tags: Med Ref Serv Q Source Type: research
About three - quarters report voluntarily telling a health care provider outside gender clinic about their identity
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People with HIV have 34 percent higher rate of COPD than those without; smoking may be to blame
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ConclusionA comparative high-resolution analysis of B*35Px or B*35Py alleles among healthy controls and HIV+ individuals showed an overrepresentation of HLA-B*35Px alleles in the healthy Indian gene pool (58%) and in the HIV+ cohort (70%). The most common B*35 subtype found among the HIV infected subjects was B*3503/55 (20%; Px group), followed by B*3501 (10%; Py group). Our study concludes that the Indian gene pool possesses higher frequency of B*35Px alleles.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
A hard-hitting YouTube documentary about Russia's HIV epidemic by a popular blogger has attracted more than 13 million views in a week and even drawn praise from the Kremlin.Reuters Health Information
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Vascular malformations associated with genetic mutations are rare and patient presentation can be complex. Misdiagnosis in this patient population is not uncommon. Time-resolved magnetic resonance angiography (TR-MRA) provides essential information about flow dynamics of a malformation that aids in establishing the correct diagnosis and appropriate treatment planning.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific e-Poster Source Type: research
This study is designed to evaluate single-center experience in postprocedural follow-up CXR after PLB and to compare utility of single vs. serial CXRs post PLB.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific e-Poster Source Type: research
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