Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist [Medical Sciences]

The mineralocorticoid receptor (MR) is highly conserved across vertebrate evolution. In terrestrial vertebrates, the MR mediates sodium homeostasis by aldosterone and also acts as a receptor for cortisol. Although the MR is present in fish, they lack aldosterone. The MR binds progesterone and spironolactone as antagonists in human MR but...

Source: Proceedings of the National Academy of Sciences - September 9, 2019 Category: Science Authors: Peter J. Fuller, Yi–Zhou Yao, Ruitao Jin, Sitong He, Beatriz Martin–Fernandez, Morag J. Young, Brian J. Smith Tags: Biological Sciences Source Type: research