Rituximab is an Effective Treatment in Patients with Pemphigus Vulgaris and Demonstrates a Steroid-Sparing Effect.
CONCLUSIONS: In patients with moderate to severe PV, rituximab plus short-term prednisone was more effective than prednisone alone. Rituximab-treated patients had less CS exposure and were less likely to experience severe or life-threatening CS-related AEs. This article is protected by copyright. All rights reserved. PMID: 31487383 [PubMed - as supplied by publisher]
We present a case report of an adult woman with AKL-positive ALCL, diagnosed by endobronchial ultrasound-guided transbronchial needle aspirate (EBUS-TBNA).A 59-year-old women with no history of breast implants, was admitted for a four-month low back pain. Initially, the patient was treated for a spondyloarthropathy, but due to persistence of the symptoms, a lumbosacral MRI was performed, showing changes in morphology and signal intensity in the vertebral body of L3, along with edema and a paravertebral collection that affected the left psoas muscle, suggesting granulomatous spondylodiscitis. Chest CT-scan showed mild left ...
ConclusionsThis large observational study based on claims data reliably identified subjects with COPD treated with open TT and their burden on the NHS. Moreover, it could describe the real clinical management of the open TT, before the marketing of the fixed one. These findings are useful for health policymakers in order to promote the appropriate utilization of both currently marketed and future therapies.
This study demonstrates that next-generation sequencing (NGS) is uniquely well suited for parental testing, in particular due to its ability to detect clinically relevant germline mosaicism. Parental variant testing by NGS was performed in a clinical laboratory for one year. The detection of mosaicism by NGS was compared to its detection by Sanger sequencing. Eight cases of previously unrevealed mosaicism were detected by NGS across eight different genes. Mosaic variants were differentiated from sequencing noise using custom bioinformatics analyses in combination with familial inheritance data and complementary Sanger sequ...
Authors: Feliciani C, Genovese G, D'astolto R, Pontini P, Marzano AV Abstract Pemphigoid gestationis (PG), also known as herpes gestationis, is the prototypic pregnancy-associated autoimmune bullous disease (AIBD), but also the other AIBDs, notably pemphigus vulgaris, may begin or exacerbate during pregnancy. Although the increase in concentration of T and B regulatory cells makes pregnancy a state of increased immunologic tolerance toward the semiallogeneic fetal antigens, a prevalent T helper (Th) 2 profile, that is reported to be associated with pregnancy, may cause exacerbation of pemphigus and AIBDs in general...
This article summarizes and weighs the risks and benefits of the various agents used to treat AIBD during pregnancy. We also present the available information on lactation as well as effects on male fertility.
Transplacental autoantibody transfer during pregnancy may cause injury in fetus. For example, congenital heart block may result from the transplacental transfer of maternal anti –SS-A antibody in patients with Sjögren syndrome. Pemphigus vulgaris (PV) is an autoimmune skin blistering disease caused by anti-desmoglein (Dsg) 3 antibody; the offspring of mothers with PV sometimes suffer from a neonatal pemphigus, and less commonly, fetal death results for unknown reasons.1 Severe skin blistering is a major issue in neonatal pemphigus, because Dsg3 is the dominant Dsg in the neonatal skin but not in the adult skin.
In this study, several triggers, including different drugs and treatments, diseases, vaccines, genetic factors, nutrients, micronutrients, pregnancy, stress, and various other triggers have been discussed. Some possible triggers, such as blood antigens and the effect of seasons have also been discussed briefly. Moreover, some protective factors against pemphigus have been reviewed. Considering the molecular mechanism of pemphigus and immune response alteration during this disease, some possible triggers have been suggested and discussed. Although those triggers may be a real threat, more studies are needed to support these hypotheses.
CONCLUSION: Evaluation of triggering factors and comorbidities before starting treatment may assist in controlling the disease more swiftly and reducing the side effects of treatment in the management of ABDs. However, to evaluate the frequency and significance of our findings in order to determine whether they are statistically significant or not, we suggest a multicenter prospective clinical trial, which would include control groups and a higher number of patients for each of the disease groups and clinical subtypes. PMID: 28618730 [PubMed - in process]
We report two young women with Pemphigus, initially treated with standard immunosuppressive medications, who expressed their wishes for pregnancy. The immunosuppressive agents were tapered and they were treated with Rituximab and IVIG, permitting discontinuation of other medications, conception and pregnancy without any oral steroids or immunosuppressive agents. Both patients maintained normal pregnancies and delivered healthy babies, supporting the use of this treatment early in the disease course of this population. PMID: 27796136 [PubMed - as supplied by publisher]
This study considers changing the T helper cells (Th1) and Th2 balance and suggests some new approaches for the better management of autoimmune diseases in pregnant women based on immune responses. Additionally, the possible role of Th17, alterations in some selected autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, systemic lupus erythematosus (SLE), atopic dermatitis (AD), asthma, and pemphigus during pregnancy, and possible associated mechanisms are discussed. This article is protected by copyright. All rights reserved.