An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing FGF7 production in outer root sheath keratinocytes.

CONCLUSION: With caveats in mind, our study identifies this osteopontin-derived peptide as an effective, novel inhibitory principle for human hair growth ex vivo and in vivo, which deserves systematic clinical testing in hirsutism and hypertrichosis. This article is protected by copyright. All rights reserved.
PMID: 31487385 [PubMed - as supplied by publisher]

Source: The British Journal of Dermatology - September 4, 2019 Category: Dermatology Authors: Alam M, Bertolini M, Gherardini J, Keren A, Ponce L, Chéret J, Alenfall J, Dunér P, Nilsson AH, Gilhar A, Paus R Tags: Br J Dermatol Source Type: research