Influence of preload and afterload on stroke volume response to low-dose dobutamine stress in patients with non-ischemic heart failure: A cardiac MR study

Abstract: Background: Lack of increase in left ventricular (LV) stroke volume (SV) during low-dose dobutamine stress (LDD) is attributed to exhausted cardiac contractile reserve in failing heart. However, the role of the afterload and preload in SV changes is underestimated. The aim of the study was to investigate the effects of LDD on preload reserve and afterload in patients with non-ischemic heart failure.Methods: 58 patients (age 62years) underwent LDD (up to 20μg/kg/min) using cardiac magnetic resonance.Results: LV-SV increased by 27% in 24 patients (p

Source: International Journal of Cardiology - December 12, 2011 Category: Cardiology Authors: Alessandro Pingitore, Giovanni Donato Aquaro, Valentina Lorenzoni, Maddalena Gallotta, Daniele De Marchi, Sabrina Molinaro, Valentina Cospite, Claudio Passino, Michele Emdin, Massimo Lombardi, Vincenzo Lionetti, Antonio L'Abbate Tags: Original Articles Source Type: research