Novel furan coupled quinoline diamide hybrid scaffolds as potent antitubercular agents: Design, synthesis and molecular modelling.

CONCLUSION: The synthesized FQD derivatives exhibited moderate to good inhibition activity especially compounds 5f, 5b and 8a exhibited very good inhibition activity due to the presence of three different scaffolds, such as INH, phenyl ketobutyric acid and fluoroquinolines. Hybridized molecules might have multiple mode of action / inhibit more than one tubercular target and could pave way for novel drug discovery in the field of tuberculosis.
PMID: 31483232 [PubMed - as supplied by publisher]

Source: Medicinal Chemistry - September 3, 2019 Category: Chemistry Authors: Rajpurohit A, Devappa SN, Pathak L, Ayyanar S, Rishinaradamangalam CR, Shoorapani P Tags: Med Chem Source Type: research