Comprehensive intra-individual genomic and transcriptional heterogeneity: evidence-based Colorectal Cancer Precision Medicine

Genome and transcriptome sequencing and editing technologies, complemented by machine learning, are revolutionizing biomedical research shaping a shift from inexact science to Precision Medicine [1 –8]. Especially for cancer, progress has been so impressive that a transition from research on spatiotemporal tumor heterogeneity [9–11] to early phase clinical trials is now beginning [4,12–17]. Precise characterization of dynamic intra-individual genomic and transcriptomic landscapes could e nhance prediction of drug response in individual patients and optimize combinatorial therapy towards clinical Cancer Precision Medicine [7,8,18,19].
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Tumour Review Source Type: research