Myalgia and statins: Separating the true from the false.

[Myalgia and statins: Separating the true from the false]. Presse Med. 2019 Aug 28;: Authors: Blacher J, Bruckert E, Farnier M, Ferrières J, Henry P, Krempf M, Mourad JJ Abstract In therapeutic trials, the incidence of adverse muscle effects under statin is low, exceptional for some authors,
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research

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Roughly six million people in Britain are thought to take statins and it is estimated that up to 30million people take the life-saving pills in the US.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionsAlthough most high-risk patients with T2D and CV disease were on lipid-lowering therapy, only 1:3 had LDL-C 
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 12 November 2019Source: American Heart JournalAuthor(s): Franck Boccara, Princy Kumar, Bruno Caramelli, Alexandra Calmy, J. Antonio G. López, Sarah Bray, Marcoli Cyrille, Robert S. RosensonBackgroundPeople living with human immunodeficiency virus (PLHIV) are at higher risk of atherosclerotic cardiovascular disease (ASCVD) due to traditional and HIV- or antiretroviral treatment (ART)-related risk factors. The use of high-intensity statin therapy is often limited by comorbidities and drug–drug interactions with ART. Herein, we present the design and baseline characteristics of ...
Source: American Heart Journal - Category: Cardiology Source Type: research
AbstractIntroductionPatients with atherosclerotic cardiovascular disease (ASCVD), especially those with recent (
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
AbstractPurpose of the ReviewPeripheral artery disease (PAD) affects close to 200 million people worldwide. Claudication is the most common presenting symptom for patients with PAD. This review summarizes the current diagnostic and treatment options for patients with claudication. Comprehensive history and physical examination in order to differentiate between claudication secondary to vascular disease vs. neurogenic causes is paramount for initial diagnosis. Ankle-brachial index is the most commonly used test for screening and diagnostic purposes. Treatment consists of four different approaches, which are best utilized in...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
Publication date: Available online 13 November 2019Source: Redox BiologyAuthor(s): Sofia-Iris Bibli, Jiong Hu, Matthias S. Leisegang, Janina Wittig, Sven Zukunft, Andrea Kapasakalidi, Beate Fisstlhaller, Diamantis Tsilimigras, Georgios Zografos, Konstantinos Filis, Ralf P. Brandes, Andreas Papapetropoulos, Fragiska Sigala, Ingrid FlemingAbstractCystathionine γ lyase (CSE) is the major source of hydrogen sulfide-derived species (H2Sn) in endothelial cells and plays an important role in protecting against atherosclerosis. Here we investigated the molecular mechanisms underlying the regulation of CSE expression in endot...
Source: Redox Biology - Category: Biology Source Type: research
A build-up of cholesterol in the brains of people with a severe form of epilepsy can cause prolonged seizures, but it may be possible to treat this with statins
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
This randomized clinical trial compares the efficacy of bempedoic acid, an experimental drug that inhibits an enzyme upstream of HMG-CoA reductase, vs placebo for lowering levels of low-density lipoprotein cholesterol (LDL-C) in patients at high cardiovascular risk with ongoing hypercholesterolemia receiving maximally tolerated lipid-lowering therapy.
Source: JAMA - Category: General Medicine Source Type: research
Since the report of the first expert panel of the National Cholesterol Education Program in 1988, effectively the first contemporary professional cholesterol guidelines in the United States, lowering of low-density lipoprotein cholesterol (LDL-C) levels has been a cornerstone of atherosclerotic cardiovascular disease (ASCVD) prevention. Consistent with classical and genetic epidemiologic studies implying a causal relationship between LDL-C and ASCVD, multiple randomized clinical trials have consistently observed proportional relationships between LDL-C lowering and ASCVD risk reduction from statins. More recently, these fi...
Source: JAMA - Category: General Medicine Source Type: research
Abstract Lipophilicity of statins has been linked to extrahepatic cells penetration and inhibition of isoprenoid synthesis and coenzyme Q10 which may affect myocardial contraction. Whether statins lipophilicity affects the risk of cardiovascular disease development in patients under dialysis is unclear. This population-based study included 114,929 patients undergoing chronic dialysis, retrieved from the Registry for Catastrophic Illness Patients from the National Health Insurance Research Database in Taiwan from 2000 to 2013. Statins were initiated after dialysis and classified into hydrophilic and lipophilic by t...
Source: Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Pharmacol Ther Source Type: research
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