Endotoxin adsorption by polymyxin B column or intraaortic balloon pumping use for severe septic cardiomyopathy

Septic patients often have low cardiac output. Some of them present severe cardiac dysfunction such as septic cardiomyopathy. However, no well-known and effective treatment for septic cardiomyopathy exists. The effect of endotoxin adsorption by polymyxin B–immobilized fiber column–direct hemoperfusion (PMX-DHP) and intraaortic balloon pumping (IABP) for septic shock remains uncertain. We experienced 2 very contrastive case reports of severe septic cardiomyopathy. We experienced 2 cases of severe septic cardiomyopathy with refractory shock. Case 1 with colon perforation presented refractory shock 6 hours after PMX-DHP, and IABP immediately improved her hemodynamics. In contrast, IABP had no effect at all in case 2 with viral enteritis, but PMX-DHP improved her blood pressure and stroke volume markedly. The probability of impaired coronary microcirculation and relative bradycardia is the least required conditions for IABP use in severe septic cardiomyopathy. Meanwhile, PMX-DHP could be a good option for septic cardiomyopathy because of its fewer complications.

Source: The American Journal of Emergency Medicine - February 11, 2013 Category: Emergency Medicine Authors: Kensuke Nakamura, Kent Doi, Ryota Inokuchi, Tatsuma Fukuda, Takahiro Hiruma, Takeshi Ishii, Susumu Nakajima, Eisei Noiri, Naoki Yahagi Tags: Case Reports Source Type: research