Prevalence of obsessive-compulsive symptoms in elderly Parkinson's disease patients: a case-control study

Parkinson's disease (PD) is a neurodegenerative disorder characterised by abnormalities in movement, behaviour, cognition and emotion. Both the disease itself and its treatment, consisting of dopaminergic replacement therapy, can cause psychiatric disorders.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Source Type: research

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Abstract Deep brain stimulation is used to alleviate symptoms of neurological and psychiatric disorders including Parkinson's disease, epilepsy, and obsessive-compulsive-disorder. Electrically stimulating limbic structures has been of great interest, and in particular, the region of the fornix. We conducted a systematic search for studies that reported clinical and preclinical outcomes of deep brain stimulation within the fornix up to July 2019. We identified 13 studies (7 clinical, 6 preclinical) that examined the effects of fornix stimulation in Alzheimer's disease (n = 9), traumatic brain injury (...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
Authors: Beszłej JA, Wieczorek T, Kobyłko A, Piotrowski P, Siwicki D, Weiser A, Fila-Witecka K, Rymaszewska J, Tabakow P Abstract Deep brain stimulation (DBS) is a treatment method that is currently getting more and more attention from psychiatrists. It has proven to be efficacious and safe in the treatment of neurological disorders, mainly Parkinson's disease (PD), dystonia and essential tremor. DBS has very often contributed to successful treatment in cases that had proved resistant to all other methods of treatment. Nowadays treatment-resistant obsessive-compulsive disorder (OCD) is the main psychiatric indica...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Authors: Pontone GM PMID: 31706637 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
ConclusionThe high beta and gamma oscillations in GPi restored after GPi ‐DBS, but not STN‐DBS. High beta and gamma oscillations may have physiological function in resisting tics in TS. The cortex compensation effect might be interfered by the STN‐DBS due to the influence on the hyper‐direct pathway but not GPi‐DBS.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
The prevalence of obsessive-compulsive disorder (OCD) and obsessive and compulsive symptoms (OCS) is unclear both in the elderly and in people with Parkinson's disease (PD). Although the typical age of onset for OCD is around age 20 there is evidence for a second peak later in life at ages 65+.1 In PD, a disease of aging, studies have produced mixed results regarding an association with OCD and OCS.2 In this issue, Monaco et al.3 found additional evidence for this second peak in that elderly whether healthy or suffering from Parkinson's disease had an unexpectedly high percentage of OCS.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Invited Perspective Source Type: research
CONCLUSIONS: Subclinical OCS were present at a high percentage in both PD patients and comparison group. The OCS phenotype in PD may present differently, as hoarding was more common in PD patients. PMID: 31558346 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
CONCLUSION: DBS of subthalamic nucleus should be seen as the most hazardous place of implantation. As a result there is a strong need of "gold standards" based on the connectivity research and closer cooperation of scientists and clinicians. PMID: 31452489 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research
Parkinson disease (PD) is a neurodegenerative disorder characterized by abnormalities in movement, behavior, cognition, and emotion. Both the disease itself and its treatment, consisting of dopaminergic replacement therapy, can cause psychiatric disorders.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Article Source Type: research
Abstract Deep brain stimulation (DBS) has evolved considerably over the past 4 decades. Although it has primarily been used to treat movement disorders such as Parkinson's disease, essential tremor, and dystonia, recently it has been approved to treat obsessive-compulsive disorder and epilepsy. Novel potential indications in both neurological and psychiatric disorders are undergoing active study. There have been significant advances in DBS technology, including preoperative and intraoperative imaging, surgical approaches and techniques, and device improvements. In addition to providing significant clinical benefit...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Authors: Berardelli I, Belvisi D, Pasquini M, Fabbrini A, Petrini F, Fabbrini G Abstract Introduction: reviewed studies that assessed the treatment of psychiatric disturbances in Parkinson's disease and atypical parkinsonisms. Neuropsychiatric disturbances in these conditions are frequent and have a profound impact on quality of life of patients and of their caregivers. It is therefore important to be familiar with the appropriate pharmacological and non-pharmacological interventions for treating these disorders. Areas covered: The authors searched for papers in English in Pubmed using the following keywords: Parkinso...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
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