Urinary extracellular vesicles associated MCP-1 and NGAL derived from specific nephron segments differ between calcium oxalate stone formers and controls.

Urinary extracellular vesicles associated MCP-1 and NGAL derived from specific nephron segments differ between calcium oxalate stone formers and controls. Am J Physiol Renal Physiol. 2019 Aug 28;: Authors: Chirackal RS, Jayachandran M, Wang X, Edeh S, Haskic Z, Perinpam M, Halling TM, Mehta R, Rivera ME, Lieske JC Abstract Randall's plaque (RP, subepithelial calcification) appears to be an important precursor of kidney stone disease. However, RP cannot be noninvasively detected. The present study investigated candidate biomarkers associated with extracellular vesicles (EVs) in the urine of calcium stone formers (CSFs) with low (
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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Conditions:   Kidney Calculi;   Nephrolithiasis;   Patient Compliance;   Calcium Oxalate Urolithiasis Intervention:   Sponsor:   EULIS Colloborative Research Working Group Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Is medical imaging making headway in its efforts to reduce patient exposure...Read more on AuntMinnie.comRelated Reading: Radiologist leadership cuts CT lung screening radiation New study links medical imaging radiation to cancer risk Concerns grow over CT radiation for kidney stones 3 ways to lower CT radiation dose across the hospital CT radiation dose levels vary widely, new study finds
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
AbstractBackgroundHyperuricemia would be a risk factor for the development/progression of CKD. However, several studies showed U-shape association between serum uric acid level and renal impairment, suggesting that hypouricemia was rather associated with renal dysfunction. Perhaps, there is the optimal target level of serum UA for renal function.MethodsThe Target-UA study is a multicenter randomized controlled trial. Eligible CKD patients (eGFR  ≥ 30, 
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
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Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Authors: Abou Chakra M, Dellis AE, Papatsoris AG, Moussa M Abstract Introduction: Urolithiasis is a common, highly recurrent disease with increasing prevalence worldwide. There are many dietary and pharmacological measures to prevent kidney stones.Areas covered: Herein, the authors explore medical expulsive therapy as well as pharmacological therapies to prevent/treat urolithiasis.Expert opinion: All stone formers should be advised to increase their fluid intake sufficiently to achieve a urine volume of at least 2.5 L/day. In the case of hypercalciuria, a thiazide diuretic should be prescribed while in cases o...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
ConclusionsGiant parathyroid adenoma is a rare cause of primary hyperparathyroidism and usually presents symptomatically  with high calcium and parathyroid hormone levels. Giant parathyroid adenoma is diagnosed by imaging and laboratory studies. Management is typically surgical, aiming at complete resection. Patients usually recover with no long-term complications or recurrence.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
CONCLUSION: Enhanced SOD activity can protect the kidneys by reducing autophagy-ERS response and CaOx kidney stone formation. Atorvastatin may be a new option for the prevention and treatment of nephrolithiasis. PMID: 31733571 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
ConclusionsOur findings show that fluoroscopy-free total ultrasound-guided PCNL represents an alternatively safe and efficient approach for the treatment of renal stones. Further study will be required to evaluate fluoroscopy-free TUPN in various clinical settings.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
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