PGC-1 α activator-induced fatty acid oxidation in tumor-infiltrating CTLs enhances effects of PD-1 blockade therapy in lung cancer.

CONCLUSIONS: Bezafibrate synergized the tumoricidal effect of PD-1 blockade in hyporesponsive lung cancer by expansion of effector CTLs within tumor microenvironment. The potential mechanism may relate to the capacity of bezafibrate in regulating FAO of tumor-infiltrating CTLs. PMID: 31451071 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31451071?dopt=Abstract

Source: Tumori - August 28, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research