Live Vaccine in Children with DiGeorge/22q11.2 Deletion Syndrome.

CONCLUSION: In our sample, live vaccines were well-tolerated, even in children with moderate T-CD4+ lymphopenia and abnormal lymphocyte proliferative responses to antigens/mitogens. PMID: 31445531 [PubMed - in process]
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research

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This study included 358 nurses. 77.7% (217) had a protective measles-specific IgG antibodies level. Protection rate was higher among workers aging 40 years (82.6% vs 68.7%; p
Source: Annali dell Istituto Superiore di Sanita - Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research
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Throughout the pandemic, Fauci has been a leading voice on safety guidelines to reduce the spread of the coronavirus and on details about therapeutics and vaccines. The list of 100 also includes public health experts who have been influential during the pandemic.WebMD Health News
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In a new report, SVB Leerink analysts looked at where the market may be overeager as investors flock to vaccine stocks.
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Publication date: October 2020Source: The Lancet Global Health, Volume 8, Issue 10Author(s): Zhuoru Zou, Christopher K Fairley, Jason J Ong, Jane Hocking, Karen Canfell, Xiaomeng Ma, Eric P F Chow, Xianglong Xu, Lei Zhang, Guihua Zhuang
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We present advances in modeling techniques that have led to fundamental disease discoveries and impacted clinical translation.Recent FindingsCombining mechanistic models and machine learning algorithms has led to improvements in the treatment ofShigella and tuberculosis through the development of novel compounds. Modeling of the epidemic dynamics of malaria at the within-host and between-host level has afforded the development of more effective vaccination and antimalarial therapies. Similarly, in-host and host-host models have supported the development of new HIV treatment modalities and an improved understanding of the i...
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As the entry sites of many pathogens such as human immunodeficiency virus (HIV), mucosal sites are defended by rapidly reacting resident memory T cells (TRM). TRMs represent a special subpopulation of memory T cells that persist long term in non-lymphoid sites without entering the circulation and provide the “sensing and alarming” role in the first-line defense against infection. The rectum and vagina are the two primary mucosal portals for HIV entry. However, compared to vaginal TRM, rectal TRM is poorly understood. Herein, we investigated the optimal vaccination strategy to induce rectal TRM. We identified an...
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US drugmaker Johnson&Johnson says the vaccine could be available for use by early 2021 if proven safe, effective. In the next phase J&J will enroll up to 60,000 volunteers across three continents and study safety and efficacy of a single vaccine dose.
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Johnson&Johnson has advanced its one-shot COVID-19 vaccine into phase 3 testing. The National Institute of Allergy and Infectious Diseases describes this as the fourth candidate to reach this stage.Medscape Medical News
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acute;ns FJ Abstract In this work we present a non-parametric data-driven approach to reverse-engineer and model the 3D passive and active responses of skeletal muscle, applied to tibialis anterior muscle of Wistar rats. We assume a Hill-type additive relation for the stored energy into passive and active contributions. The terms of the stored energy have no upfront assumed shape, nor material parameters. These terms are determined directly from experimental data in spline form solving numerically the functional equations of the tests from which experimental data is available. To characterize typical longitudinal-...
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