Chronic Antidepressant Treatment Impairs the Acquisition of Fear Extinction

Conclusions: These results provide further evidence that chronic antidepressant treatment can impair amygdala-dependent learning. Our findings are consistent with a role for glutamatergic neurotransmission in the final common pathway of antidepressant treatment.

Source: Biological Psychiatry - December 20, 2012 Category: Psychiatry Authors: Nesha S. Burghardt, Torfi Sigurdsson, Jack M. Gorman, Bruce S. McEwen, Joseph E. LeDoux Tags: Archival Reports Source Type: research