1010 - characterizing hoxa-expressing endothelial and haematopoietic populations derived from human pluripotent stem cells

Haematopoietic stem cell (HSC) transplantation is a key therapy for patients with leukaemia or bone marrow failure. Repopulating HSCs derived from human pluripotent stem cells (hPSCs) would provide a source of blood stem cells for many patients who might benefit from this therapy but lack a suitable donor.Success is contingent on the development of hPSC differentiation protocols that generate and support the developmental continuum from correctly patterned haemogenic endothelium to the emerging preHSCs, and their subsequent maturation to repopulating (r) HSCs.

Source: Experimental Hematology - July 31, 2019 Category: Hematology Authors: Elizabeth Ng, Jasna Kusur, Tanya Labonne, Edouard Stanley, Andrew Elefanty Source Type: research