1013 - chromatin proteins in haematopoietic stem cells and haematological malignancies

A major focus of our work is the role of chromatin modifying complexes in normal haematopoiesis and in leukaemia. For example, somatically acquired mutations in the plant homeodomain finger 6 gene (PHF6) frequently occur in haematopoietic malignancies and often coincide with ectopic expression of TLX3. However, there is no functional evidence to demonstrate whether these mutations contribute to tumourigenesis. Similarly, the role of PHF6 in haematopoiesis is unknown. We found that Phf6 deletion in mice resulted in a reduced number of haematopoietic stem cells (HSCs), an increased number of haematopoietic progenitor cells, and an increased proportion of cycling stem and progenitor cells.

Source: Experimental Hematology - July 31, 2019 Category: Hematology Authors: Anne Voss, Tim Thomas, Helen McRae Source Type: research