Metabolomics for predicting hyperglycemia in pregnancy: a protocol for a systematic review and potential meta-analysis

The objective of this systematic review is to assess the performance of metabolomic markers in the prediction of HIP.MethodsThis is a protocol for a systematic review with potential meta-analysis. The primary outcome is GDM, defined as glucose intolerance identified in the second and third trimesters of pregnancy (any FPG ≥ 92 mg/dL and<  126 mg/dL OR when 75-g OGTT shows one altered value among these: FPG ≥ 92 mg/dL or 1-h post glucose load ≥ 180 mg/dL or 2-h post glucose load ≥ 153 mg/dL); the secondary outcome is HIP, defined as hyperglycemia detected in the first trimester of pregnancy (any FPG ≥ 126  mg/dL). A detailed systematic literature search will be carried out in electronic databases and conference abstracts, using the keywords “gestational diabetes mellitus,” “metabolomics,” “pregnancy,” and “screening” (and their variations). We will include original peer-reviewed articl es published from Jan 1, 1999, to Dec 31, 2018. Original studies including diabetes diagnosed before pregnancy (T2DM and T1DM), multiple pregnancies, and congenital malformations will be excluded. All results regarding samples, participant characteristics, metabolomic techniques, and diagnostic accu racy measures will be retrieved and analyzed. Since this is a systematic review, no ethical approval is necessary.DiscussionThis systematic review may have the potential to provide significant evidence-based findings on the prediction performance o...
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research