Generation of 3 clones of induced pluripotent stem cells (iPSCs) from a patient affected by Crohn's disease

Publication date: Available online 23 August 2019Source: Stem Cell ResearchAuthor(s): Lanzi Gaetana, Masneri Stefania, Ferraro Rosalba Monica, Genova Elena, Piovani Giovanna, Barisani Chiara, Pelin Marco, Stocco Gabriele, Decorti Giuliana, Bramuzzo Matteo, Giliani SilviaAbstractCrohn's disease is a debilitating and incurable chronic inflammatory bowel disease, affecting millions of individuals worldwide, with an increasing frequency. Surgery must be applicable in half of the cases often with a disabling course, and pharmacological treatments may have adverse complications. We generated three isogenic clones of iPSCs from peripheral blood mononuclear cells (PBMCs) of a patient with Crohn's Disease under pharmacological treatment without adverse effects. Sendai virus based vector was used and the iPSCs were characterized for genetic uniqueness, genomic integrity, pluripotency, and differentiation ability. These iPSCs will be a powerful tool to develop tailored therapies.
Source: Stem Cell Research - Category: Stem Cells Source Type: research

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Condition:   Crohn Colitis Interventions:   Drug: remesetemcel-L;   Other: Placebo Sponsors:   The Cleveland Clinic;   Mesoblast, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Rectovaginal Fistula;   Crohn Disease;   Crohn Disease of Vulva;   Rectolabial; Fistula Interventions:   Drug: Mesenchymal Stem Cells;   Other: Placebo Sponsor:   The Cleveland Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Perianal Crohn Disease;   Perianal Fistula;   Crohn Disease Interventions:   Drug: Mesenchymal Stem Cells;   Other: Placebo Sponsor:   The Cleveland Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Rectovaginal Fistula;   Crohn Disease;   Crohn Disease of Vulva;   Rectolabial; Fistula Interventions:   Drug: Mesenchymal Stem Cells;   Other: Placebo Sponsor:   The Cleveland Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Ileal Pouch;   Crohn Disease Interventions:   Drug: Mesenchymal stem cells;   Other: Placebo Sponsor:   The Cleveland Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Perianal Crohn Disease;   Perianal Fistula;   Crohn Disease Interventions:   Drug: Mesenchymal Stem Cells;   Other: Placebo Sponsor:   The Cleveland Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Rectovaginal Fistula;   Crohn Disease;   Crohn Disease of Vulva;   Rectolabial; Fistula Interventions:   Drug: Mesenchymal Stem Cells;   Other: Placebo Sponsor:   The Cleveland Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Ileal Pouch;   Crohn Disease Interventions:   Drug: Mesenchymal stem cells;   Other: Placebo Sponsor:   The Cleveland Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Perianal Crohn Disease;   Perianal Fistula;   Crohn Disease Interventions:   Drug: Mesenchymal Stem Cells;   Other: Placebo Sponsor:   The Cleveland Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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