Technological Advancements in Magnetic Resonance Neurography

AbstractPurpose of ReviewMagnetic resonance neurography (MRN) is being increasingly used as a problem-solving tool for diagnosis and management of peripheral neuropathies. This review is aimed at summarizing important technological advances, including MR pulse sequence and surface coil developments, which have facilitated MRN ’s use in clinical practice.Recent FindingsThe most recent research in MRN focuses on its clinical applications, with concomitant development of three-dimensional, parallel imaging and vascular suppression techniques that facilitate higher spatial resolution and depiction of small nerve branches arising from the brachial and lumbosacral plexi as well as fascicular abnormalities of more distal extremity nerves. Quantitative diffusion tensor imaging (DTI) has been studied as a tool to detect microstructural abnormalities of peripheral nerves and more precisely define grades of nerve injury but will require additional investigation to determine its role in daily clinical practice.SummaryMRN continues to evolve due to technological improvements and awareness by the medical community of its capabilities. Additional technological developments related to surface coil designs and vascular suppression techniques will be needed to move the field forward.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research

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We report three cases of focal anterior interosseous fascicular involvement in the median nerve trunk presenting as AIN palsy. Our report emphasizes the unique ultrasonographic and magnetic resonance imaging (MRI) features of swelling, hourglass-like constriction and torsion, and entwinement of the nerve fascicle of the dorsal region of the median nerve, which were confirmed surgically. On MRI, all patients showed denervation changes in the AIN territory, as well as in the median nerve territory, without compressing structures. PMID: 32469179 [PubMed - in process]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
AbstractOxaliplatin (OXA) is a commonly used platinum-based chemotherapy drug for colorectal cancer. OXA-induced peripheral neurotoxcity (OIPN) is a comprehensive adverse reaction of OXA. OIPN can be divided into acute and chronic types according to clinical features and different mechanisms. The main clinical features of acute OIPN are cold-sensitive sensory symptoms and neuropathic pain in limbs. In addition to the above symptoms, chronic OIPN also produces autonomic nerve dysfunction. The most important mechanism involved in acute OIPN is the alteration of voltage-gated Na  + channels, and nuclear DNA dama...
Source: Journal of Neurology - Category: Neurology Source Type: research
Authors: Ota K, Yamaguchi R, Tsukahara A, Nishida S, Shigekiyo T, Harada S, Kojima Y, Takeuchi T, Arawaka S, Higuchi K Abstract A 68-year-old woman presented with a 2-year history of worsening unsteady gait. Her neurological examination revealed peripheral neuropathy with lower limb sensory dominance. T2-weighted imaging revealed a disorder of the posterior cervical cord. Blood test findings revealed vitamin B12 deficiency, and gastroscopy revealed typical findings of autoimmune gastritis. She received vitamin B12 supplementation, but some peripheral neuropathy symptoms persisted due to longstanding vitamin B12 def...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Sports-related peripheral neuropathies account for 6% of all peripheral neuropathies and most commonly involve the upper extremity. The routes of the median, radial, and ulnar nerves are positioned in arrangements of pulleys and sheaths to glide smoothly a...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Egress, Escape, Evacuation, Crowds Source Type: news
Conditions:   Neuropathy;Peripheral;   Chemotherapy-induced Peripheral Neuropathy;   Neuropathy Interventions:   Device: Voxx Human Performance Technology Socks;   Device: Placebo Socks Sponsors:   Arash Asher, MD;   VoxxLife Not yet recruiting
Source: - Category: Research Source Type: clinical trials
AbstractThe diagnosis of peripheral neuropathies can be challenging with consequent difficulties in patients ’ management. The aim of this study was to explore the current diagnostic role of sural nerve biopsy and to compare pathological findings with serum neurofilament light chain levels (NfL) as biomarkers of axonal damage. We collected demographic, clinical, and paraclinical data of patients referred over 1 year to the Neurology Unit, University of Verona, Italy, to perform nerve biopsy for diagnostic purposes, and we analyzed NfL levels in available paired sera using a high sensitive technique (Quanterix, S...
Source: Journal of Neurology - Category: Neurology Source Type: research
Conclusion Contactin-1 IgG has a distinct sensory predominant presentation commonly associated with neuropathic pain, with demyelinating changes on electrophysiologic studies. A paraneoplastic cause should be considered. Testing of contactin-1 IgG among cases with similar presentations may guide immunotherapy selection, especially second-line immunotherapy consideration.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autoimmune diseases, Peripheral neuropathy, Chronic inflammatory demyelinating polyneuropathy, Neuropathic pain Article Source Type: research
J Neurol Surg A Cent Eur Neurosurg DOI: 10.1055/s-0040-1701619 Study Aims Electromyographic (EMG) recordings of the fibularis longus and tibialis anterior muscles were performed intraoperatively during nerve decompression (ND) of the common fibular nerve (CFN) in patients with symptomatic diabetic sensorimotor peripheral neuropathy. Patient demographics and clinical attributes were compared against changes in EMG after ND and analyzed for possible correlations. Methods Intraoperative changes in CFN EMG were analyzed for correlations against sex, age, body mass index (BMI), hemoglobin A1c (A1c), and type and...
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - Category: Neurosurgery Authors: Tags: Original Article Source Type: research
This article demonstrates the power and flexibility of linear mixed-effects models (LMEMs) to investigate high-density surface electromyography (HD-sEMG) signals. The potentiality of the model is illustrated by investigating the root mean squared value of HD-sEMG signals in the tibialis anterior muscle of healthy (n = 11) and individuals with diabetic peripheral neuropathy (n = 12). We started by presenting the limitations of traditional approaches by building a linear model with only fixed effects. Then, we showed how the model adequacy could be increased by including random effects, as well as...
Source: Medical and Biological Engineering and Computing - Category: Biomedical Engineering Source Type: research
Publication date: July 2020Source: Biomedicine &Pharmacotherapy, Volume 127Author(s): Jun Xie, Wei Song, Xiaochun Liang, Qian Zhang, Yue Shi, Wei Liu, Xiaohu Shi
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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