TREM1 Blockade: Killing Two Birds with One Stone.

TREM1 Blockade: Killing Two Birds with One Stone. Trends Immunol. 2019 Aug 20;: Authors: Colonna M Abstract Infectious and sterile injuries cause the release of PAMPs and DAMPs. A study by Liu et al. (Nat. Immunol. 2019) reports that DAMP-induced sterile brain inflammation from stroke is associated with sympathetic nervous system activation, enhancing intestinal permeability, the release of microbiota-derived PAMPs, and inflammation. TREM1 is implicated as a potential target to treat stroke and DAMP- and PAMP-induced inflammation. PMID: 31439414 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31439414?dopt=Abstract

Source: Trends in Immunology - August 19, 2019 Category: Allergy & Immunology Authors: Colonna M Tags: Trends Immunol Source Type: research