P9. Dimethyloxaloylglycine (DMOG) preconditioning of adipose-derived mesenchymal stem cells as strategy for enhancing posterolateral lumbar fusion in a rat model

Transplantation of adipose-derived mesenchymal stem cells (ADSCs) has become a promising approach for bone regeneration therapies, particularly in elderly patients. However, poor cell survival in vivo after implantation due to the ischemic tissue environment has been one of the major limitations of the effectiveness of this strategy. Hypoxia Inducible Factor-1 α (HIF-1α) plays an important role in angiogenic-osteogenic coupling during bone regeneration, as it is a critical mediator of the adaptive cell response to hypoxia.
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research